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Synfacts 2006(12): 1247-1247  
DOI: 10.1055/s-2006-949490
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rh-Catalyzed One-Pot Conjugate Addition and Indium-Mediated Allylation

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
S. Källström, R. B. C. Jagt, R. Sillanpää, B. L. Feringa, A. J. Minnaard*, R. Leino*
University of Groningen, The Netherlands, Åbo, Akademi University , and University of Jyväskylä, Finland
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

The ability to construct highly complex building blocks quickly without purification has become increasingly more attractive as the yields and diastereoselectivites have increased. The authors describe efficient syntheses which employ several asymmetric conjugate addition and subsequent diastereoselective allylation reactions. Furthermore, they show the application of this system to the synthesis of a spirocyclic compound only performing one purification over four steps.