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Synfacts 2006(10): 1029-1029
DOI: 10.1055/s-2006-949285
DOI: 10.1055/s-2006-949285
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Tetra-ortho-substituted Axially Chiral Biaryls via [2+2+2] Cycloadditions
G. Nishida, N. Suzuki, K. Noguchi, K. Tanaka*
Tokyo University of Agriculture and Technology, Japan
Further Information
Publication History
Publication Date:
21 September 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200610/lookinside/thumbnails/10.1055-s-2006-949285-1.jpg)
Significance
Complex axially chiral biaryls can be prepared in one step from two acyclic starting materials. Besides this method, very few methods allow the preparation of tetra-ortho-substituted biaryl compounds. With the double [2+2+2] cycloaddition, in most cases the mono-annulated products 7 are observed and can be resubjected to a second cycloaddition to obtain non-symmetrically substituted biaryl compounds 8 with high enantioselectivity.