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Synfacts 2006(10): 1040-1040  
DOI: 10.1055/s-2006-949278
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ru(II)/Chiral Diphosphonite Asymmetric Keto Ester Hydrogenation

Contributor(s): Mark Lautens, Andrew Martins
M. T. Reetz*, X. Li
Max-Planck-Institut für Kohlenforschung, Mühlheim/Ruhr, Germany
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Publication History

Publication Date:
21 September 2006 (online)

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Significance

Using a Ru(II)/BINOL-derived diphosphonite catalyst system, several β-keto esters were enantioselectively hydrogenated to the corresponding β-hydroxy esters with excellent yields and ee values. The catalyst was also used for the dynamic kinetic resolution of a cyclic β-keto ester to yield a single diastereomer, but was unsuccessful in doing so for an acyclic case.