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Synfacts 2006(9): 0920-0920  
DOI: 10.1055/s-2006-949245
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Simmons-Smith Cyclopropanation of Silyl Enol Ethers

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
H. Du, J. Long, Y. Shi*
Colorado State University, Fort Collins, USA
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Publication History

Publication Date:
23 August 2006 (online)

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Significance

Simmons-Smith cyclopropanation typically requires a free hydroxyl functionality to direct the reaction. Using this new protocol, cyclopropanol derivatives can be synthesized in high yields and enantioselectivity from prochiral enolates.