Affektive Mischzustände bei Bipolaren Störungen: ein Überblick

Zusammenfassung

Affektive Mischzustände bei bipolaren Störungen sind derzeit Gegenstand zahlreicher wissenschaftlicher Diskussionen und stellen ein komplexes Krankheitsbild dar, in dem sowohl Symptome einer Manie als auch einer Depression gleichzeitig vorhanden sind. Außerdem sind Mischzustände durch eine große Vielzahl an Symptomen (Symptompolymorphismus) und eine Syndromlabilität (intraepisodisches Switching) gekennzeichnet. Deswegen stellt die Behandlung bipolar affektiver Mischzustände eine wichtige und besondere Herausforderung dar. Bislang erschweren diagnostische Unschärfen die systematische klinische Untersuchung dieser Patientengruppe, so dass gegenwärtig keine allgemeingültigen Richtlinien existieren. In dieser Übersichtsarbeit werden der Stellenwert sowie Probleme und Risiken aktueller Therapieoptionen diskutiert.

Abstract

Affective mixed states in bipolar disorders are a current matter of scientific debate and represent a complex clinical picture with coexisting manic and depressive symptoms. Treatment of mixed states is regarded as an important challenge. As diagnostic uncertainties complicate systematic clinical evaluations of this patient group, generally accepted clinical treatment guidelines are lacking yet. In this review the significance as well as the problems and risks of new treatment options are discussed.

Schlüsselwörter

Affektive Mischzustände - Bipolare Störungen - Pharmakotherapie

Key words

affective mixed states - bipolar disorder - Phamacotherapy

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