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Synfacts 2006(8): 0804-0804
DOI: 10.1055/s-2006-942021
DOI: 10.1055/s-2006-942021
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Asymmetric Epoxidation with Aqueous Hydrogen Peroxide as the Oxidant
Y. Sawada, K. Matsumoto, S. Kondo, H. Watanabe, T. Ozawa, K. Suzuki, B. Saito, T. Katsuki*
Kyushu University, Fukuoka and Nissan Chemical Industries, LTD., Japan
Further Information
Publication History
Publication Date:
21 July 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200608/lookinside/thumbnails/10.1055-s-2006-942021-1.jpg)
Significance
This report describes the synthesis of a ligand for the epoxidation of unfunctionalized olefins using hydrogen peroxide. The active catalyst is a titanium-peroxo species. The optimal reaction conditions were room temperature with dichloromethane as the solvent and 1.5 equivalents of hydrogen peroxide. The reaction conditions were effective for the epoxidation of terminal, cis-disubstituted and trisubstituted olefins.