Regio- and Stereoselective Allylic Alkylations of Chelated Enolates

Significance

Here the authors report on rhodium-catalyzed allylic alkylation. Phosphates as leaving groups were shown to be superior compared to other leaving groups typically used in these types of reactions (i.e., acetate). Trimethyl and triethyl phosphite were shown to be the most effective ligands and trifluoroacetyl was the best protecting group for the chelated glycine enolate nucleophile.