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Synfacts 2006(8): 0826-0826
DOI: 10.1055/s-2006-942007
DOI: 10.1055/s-2006-942007
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Simple Preparation of Esters from Grignard Reagents and Alcohols
T. Werner, A. G. M. Barrett*
Imperial College London, UK
Further Information
Publication History
Publication Date:
21 July 2006 (online)
Significance
This procedure is a highly practical method for the preparation of esters directly from Grignard reagents and alcohols, avoiding a separate step of isolation of the corresponding carboxylic acid. Functional groups like an ester in the alcohol molecule are tolerated. The reaction is very simple to perform and affords good to excellent yields of products. Primary, secondary and benzylic alcohols as well as the variety of other Grignard reagents were shown to react smoothly in this new acylation procedure.