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Synfacts 2006(8): 0747-0747
DOI: 10.1055/s-2006-941933
DOI: 10.1055/s-2006-941933
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Dolabelide D
P. K. Park, S. J. O’Malley, D. R. Schmidt, J. L. Leighton*
Columbia University, New York, USA
Further Information
Publication History
Publication Date:
21 July 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200608/lookinside/thumbnails/10.1055-s-2006-941933-1.jpg)
Significance
Dolabelide D is a cytotoxic 24-membered macrolide isolated from the sea hare Dolabella auricularia. The Leighton group reports the first total synthesis of Dolabelide D making extensive use of their catalytic asymmetric silane alcoholysis and Rh-catalyzed tandem silylformylation/crotylsilylation reactions.