Cu-Promoted Coupling of Imines, Acid Chlorides and Organoindium Reagents

Significance

This is a new useful three-component reaction, leading directly, with a broad diversity, to interesting polyfunctionalized amides. The use of organoindium compounds allows an excellent tolerance of functional groups, which is important in the synthesis of complex biologically active compounds. A very broad range of substrates can be involved in the reaction: alkyl- and arylimines, alkyl-, vinyl- and arylindium compounds react equally well. The use of α,β-unsaturated imines leads exclusively to 1,4-addition products.