Combined Heck-Suzuki Reactions in a Synthesis of Lennoxamine

S. Couty; C. Meyer; J. Cossy

doi:10.1055/s-2006-941842

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Synfacts 2006(7): 0652-0652
DOI: 10.1055/s-2006-941842

Synthesis of Heterocycles

Combined Heck-Suzuki Reactions in a Synthesis of Lennoxamine

Contributor(s): Victor Snieckus, Yigang Zhao
S. Couty, C. Meyer, J. Cossy*
ESPCI, Paris, France

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Publication History

Publication Date:
22 June 2006 (online)

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Significance

A key step in the reported synthesis of lennoxamine (4) involves a one-pot Pd-catalyzed Heck-Suzuki-Miyaura reaction. Thus, treatment of the ynamide 2 under the typical Heck conditions in the presence of base (obligatory for the Suzuki-Miyaura process) leads to the isoindolinone 3 in good yield.