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Synfacts 2006(7): 0685-0685
DOI: 10.1055/s-2006-941812
DOI: 10.1055/s-2006-941812
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Reductive Coupling of Alkynes and α-Keto Aldehydes
C.-W. Cho, M. J. Krische*
University of Texas at Austin, USA
Further Information
Publication History
Publication Date:
22 June 2006 (online)
Significance
The hydrogen-mediated reductive coupling protocols developed by this group represent a very nice means for the synthesis of important synthetic interemediates. Only 1 atm of H2 is needed and a catalytic amount of carboxylic acid is used to accelerate the reaction. Various ligands were tested, and tol-BINAP was shown to be superior. The synthetically useful compound is obtained with high enantioselectivity (91% ee).