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Synfacts 2006(5): 0422-0422  
DOI: 10.1055/s-2006-934390
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Batzelladines A and D

Contributor(s): Philip Kocienski, Thomas Snaddon
J. Shimokawa, T. Ishiwata, K. Shirai, H. Koshino, A. Tanatani, T. Nakata, Y. Hashimoto, K. Nagasawa*
Tokyo University of Agriculture and Technology, University of Tokyo, RIKEN and Tokyo University of Science, Japan
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Publication History

Publication Date:
21 April 2006 (online)

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Significance

The Batzelladines are polycyclic guanidine alkaloids that interrupt protein-protein interactions. Of particular interest is their potential for application in AIDS treatments. Nagasawa and co-workers employed Ali’s sequential 1,3-dipolar cycloaddition of nitrones approach (S. K. Ali, M. I. Wazeer Tetrahedron Lett. 1993, 34, 137-140) to construct H, a precursor to the tricyclic guanidine core.