Novel Zn(pybox) Catalyst for Asymmetric Aqueous Mukaiyama Aldol Reactions

J. Jankowska; J. Mlynarski

doi:10.1055/s-2006-934356

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Synfacts 2006(5): 0462-0462
DOI: 10.1055/s-2006-934356

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Novel Zn(pybox) Catalyst for Asymmetric Aqueous Mukaiyama Aldol Reactions

Contributor(s): Mark Lautens, Yann Béthuel
J. Jankowska, J. Mlynarski*
Polish Academy of Sciences, Warsaw, Poland

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Publication History

Publication Date:
21 April 2006 (online)

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Significance

The development of a new Zn(pybox) catalyst system for aqueous Mukaiyama aldol reaction is reported. Good to high enantiomeric excesses could be obtained without erosion of the diastereoselectivity for a wide range of aldehydes including aliphatic analogues.