ABSTRACT
Ventilator-associated pneumonias (VAPs) due to methicillin-resistant Staphylococcus aureus (MRSA) are rising in incidence and pose unique challenges in their prevention and treatment. Risk factors for the development of MRSA VAP include nasal carriage, prior antibiotic therapy, prolonged mechanical ventilation, poor infection control practices, head trauma/coma, and viral infection. Measures to prevent the development of MRSA VAP include general VAP prevention strategies and reduction of S. aureus nasal carriage. S. aureus possesses a variety of transferable genetic elements that encode proteins conferring resistance to several antibiotics, including β-lactams and glycopeptides. Successful treatment of MRSA VAP with currently available antibiotics has been poor. Current management guidelines recommend glycopeptides as initial therapy for MRSA VAP. However vancomycin success rates are low, ranging from only 35 to 57%. This may be due to the poor penetration of vancomycin into the lung, and alternate dosing regimens to increase tissue levels need to be further studied. Treatment with linezolid, which penetrates well into the lung, is associated with higher cure and survival rates. Further data are needed to evaluate the efficacy of new antibiotics in MRSA VAP.
KEYWORDS
Methicillin-resistance -
S. aureus
- pneumonia - ventilator-associated pneumonia - vancomycin - linezolid
REFERENCES
-
1
McGahee W, Lowy F D.
Staphylococcal infections in the intensive care unit.
Semin Respir Infect.
2000;
15
308-313
-
2
Noskin G A, Rubin R J, Schentag J J et al..
The burden of Staphylococcus aureus infections on hospitals in the United States: an analysis of the 2000 and 2001 Nationwide Inpatient Sample Database.
Arch Intern Med.
2005;
165
1756-1761
-
3
Chambers H F.
Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications.
Clin Microbiol Rev.
1997;
10
781-791
-
4
Fridkin S K.
Increasing prevalence of antimicrobial resistance in intensive care units.
Crit Care Med.
2001;
29
N64-68
-
5
Streit J M, Jones R N, Sader H S, Fritsche T R.
Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001).
Int J Antimicrob Agents.
2004;
24
111-118
-
6
Fluit A C, Verhoef J, Schmitz F J.
Frequency of isolation and antimicrobial resistance of gram-negative and gram-positive bacteria from patients in intensive care units of 25 European university hospitals participating in the European arm of the SENTRY Antimicrobial Surveillance Program 1997-1998.
Eur J Clin Microbiol Infect Dis.
2001;
20
617-625
-
7
Ho P L.
Carriage of methicillin-resistant Staphylococcus aureus, ceftazidime-resistant gram-negative bacilli, and vancomycin-resistant enterococci before and after intensive care unit admission.
Crit Care Med.
2003;
31
1175-1182
-
8
Hubmayr R D, Burchardi H, Elliot M et al..
Statement of the 4th International Consensus Conference in Critical Care on ICU-Acquired Pneumonia-Chicago, Illinois, May 2002.
Intensive Care Med.
2002;
28
1521-1536
-
9
Fagon J Y, Chastre J, Hance A J, Montravers P, Novara A, Gibert C.
Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay.
Am J Med.
1993;
94
281-288
-
10
Heyland D K, Cook D J, Griffith L, Keenan S P, Brun-Buisson C.
The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group.
Am J Respir Crit Care Med.
1999;
159
1249-1256
-
11
Torres A, Carlet J.
Ventilator-associated pneumonia. European Task Force on ventilator-associated pneumonia.
Eur Respir J.
2001;
17
1034-1045
-
12
Trouillet J L, Chastre J, Vuagnat A et al..
Ventilator-associated pneumonia caused by potentially drug-resistant bacteria.
Am J Respir Crit Care Med.
1998;
157
531-539
-
13
Rello J, Sa-Borges M, Correa H, Leal S R, Baraibar J.
Variations in etiology of ventilator-associated pneumonia across four treatment sites: implications for antimicrobial prescribing practices.
Am J Respir Crit Care Med.
1999;
160
608-613
-
14
Babcock H M, Zack J E, Garrison T, Trovillion E, Kollef M H, Fraser V J.
Ventilator-associated pneumonia in a multi-hospital system: differences in microbiology by location.
Infect Control Hosp Epidemiol.
2003;
24
853-858
-
15
Namias N, Samiian L, Nino D et al..
Incidence and susceptibility of pathogenic bacteria vary between intensive care units within a single hospital: implications for empiric antibiotic strategies.
J Trauma.
2000;
49
638-645
discussion 645-646
-
16
Ibrahim E H, Ward S, Sherman G, Schaiff R, Fraser V J, Kollef M H.
Experience with a clinical guideline for the treatment of ventilator-associated pneumonia.
Crit Care Med.
2001;
29
1109-1115
-
17
American Thoracic Society/Infactious Diseases Society of America .
Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia.
Am J Respir Crit Care Med.
2005;
171
388-416
-
18
Fagon J Y, Chastre J, Domart Y et al..
Nosocomial pneumonia in patients receiving continuous mechanical ventilation: prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques.
Am Rev Respir Dis.
1989;
139
877-884
-
19
Wunderink R G, Cammarata S K, Oliphant T H, Kollef M H.
Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia.
Clin Ther.
2003;
25
980-992
-
20
Rello J, Sole-Violan J, Sa-Borges M et al..
Pneumonia caused by oxacillin-resistant Staphylococcus aureus treated with glycopeptides.
Crit Care Med.
2005;
33
1983-1987
-
21
Rello J, Torres A, Ricart M et al..
Ventilator-associated pneumonia by Staphylococcus aureus: comparison of methicillin-resistant and methicillin-sensitive episodes.
Am J Respir Crit Care Med.
1994;
150
1545-1549
-
22
Gonzalez C, Rubio M, Romero-Vivas J, Gonzalez M, Picazo J J.
Bacteremic pneumonia due to Staphylococcus aureus: a comparison of disease caused by methicillin-resistant and methicillin-susceptible organisms.
Clin Infect Dis.
1999;
29
1171-1177
-
23
Cosgrove S E, Sakoulas G, Perencevich E N, Schwaber M J, Karchmer A W, Carmeli Y.
Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis.
Clin Infect Dis.
2003;
36
53-59
-
24
Foster T J.
The Staphylococcus aureus “superbug”.
J Clin Invest.
2004;
114
1693-1696
-
25
Sanford M D, Widmer A F, Bale M J, Jones R N, Wenzel R P.
Efficient detection and long-term persistence of the carriage of methicillin-resistant Staphylococcus aureus
.
Clin Infect Dis.
1994;
19
1123-1128
-
26
Huang S S, Platt R.
Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization.
Clin Infect Dis.
2003;
36
281-285
-
27
Naimi T S, LeDell K H, Como-Sabetti K et al..
Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection.
JAMA.
2003;
290
2976-2984
-
28
Tobin-D Anglo M, Arnold K, Lance-Park .
Methicillin-resistant Staphylococcus aureus infections in correctional facilities-Georgia, California, and Texas, 2001-2003.
MMWR Morb Mortal Wkly Rep.
2003;
52
992-996
-
29
Outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections-Los Angeles County, California, 2002-2003.
MMWR Morb Mortal Wkly Rep.
2003;
52
88
-
30
Gantz N, Harmon H, Hondy H et al..
Methicillin-resistant Staphylococcus aureus infections among competitive sports participants-Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000-2003.
MMWR Morb Mortal Wkly Rep.
2003;
52
793-795
-
31
Kaplan S L, Hulten K G, Gonzalez B E et al..
Three-year surveillance of community-acquired Staphylococcus aureus infections in children.
Clin Infect Dis.
2005;
40
1785-1791
-
32
Frazee B W, Lynn J, Charlebois E D, Lambert L, Lowery D, Perdreau-Remington F.
High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections.
Ann Emerg Med.
2005;
45
311-320
-
33
Young D M, Harris H W, Charlebois E D et al..
An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients.
Arch Surg.
2004;
139
947-951
discussion 951-953
-
34
Deryke C A, Lodise Jr T P, Rybak M J, McKinnon P S.
Epidemiology, treatment, and outcomes of nosocomial bacteremic Staphylococcus aureus pneumonia.
Chest.
2005;
128
1414-1422
-
35
MacDougall C, Powell J P, Johnson C K, Edmond M B, Polk R E.
Hospital and community fluoroquinolone use and resistance in Staphylococcus aureus and Escherichia coli in 17 US hospitals.
Clin Infect Dis.
2005;
41
435-440
-
36
Monnet D L, MacKenzie F M, Lopez-Lozano J M et al..
Antimicrobial drug use and methicillin-resistant Staphylococcus aureus, Aberdeen, 1996-2000.
Emerg Infect Dis.
2004;
10
1432-1441
-
37
El-Solh A A, Pietrantoni C, Bhat A et al..
Microbiology of severe aspiration pneumonia in institutionalized elderly.
Am J Respir Crit Care Med.
2003;
167
1650-1654
-
38
Drinka P J, Gauerke C, Le D.
Antimicrobial use and methicillin-resistant Staphylococcus aureus in a large nursing home.
J Am Med Dir Assoc.
2004;
5
256-258
-
39
Mendelson G, Yearmack Y, Granot E, Ben-Israel J, Colodner R, Raz R.
Staphylococcus aureus carrier state among elderly residents of a long-term care facility.
J Am Med Dir Assoc.
2003;
4
125-127
-
40
Pujol M, Corbella X, Pena C et al..
Clinical and epidemiological findings in mechanically ventilated patients with methicillin-resistant Staphylococcus aureus pneumonia.
Eur J Clin Microbiol Infect Dis.
1998;
17
622-628
-
41
Lucet J C, Paoletti X, Lolom I et al..
Successful long-term program for controlling methicillin-resistant Staphylococcus aureus in intensive care units.
Intensive Care Med.
2005;
31
1051-1057
-
42
Hsieh A H, Bishop M J, Kubilis P S, Newell D W, Pierson D J.
Pneumonia following closed head injury.
Am Rev Respir Dis.
1992;
146
290-294
-
43
Rello J, Ausina V, Ricart M, Puzo C, Net A, Prats G.
Nosocomial pneumonia in critically ill comatose patients: need for a differential therapeutic approach.
Eur Respir J.
1992;
5
1249-1253
-
44
Berrouane Y, Daudenthun I, Riegel B et al..
Early onset pneumonia in neurosurgical intensive care unit patients.
J Hosp Infect.
1998;
40
275-280
-
45
Bronchard R, Albaladejo P, Brezac G et al..
Early onset pneumonia: risk factors and consequences in head trauma patients.
Anesthesiology.
2004;
100
234-239
-
46
Campbell W, Hendrix E, Schwalbe R, Fattom A, Edelman R.
Head-injured patients who are nasal carriers of Staphylococcus aureus are at high risk for Staphylococcus aureus pneumonia.
Crit Care Med.
1999;
27
798-801
-
47
Ewig S, Torres A, El-Ebiary M et al..
Bacterial colonization patterns in mechanically ventilated patients with traumatic and medical head injury: incidence, risk factors, and association with ventilator-associated pneumonia.
Am J Respir Crit Care Med.
1999;
159
188-198
-
48
Sirvent J M, Torres A, Vidaur L, Armengol J, de Batlle J, Bonet A.
Tracheal colonisation within 24 h of intubation in patients with head trauma: risk factor for developing early-onset ventilator-associated pneumonia.
Intensive Care Med.
2000;
26
1369-1372
-
49
Gillet Y, Issartel B, Vanhems P et al..
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients.
Lancet.
2002;
359
753-759
-
50
Bassetti S, Bischoff W E, Walter M et al..
Dispersal of Staphylococcus aureus into the air associated with a rhinovirus infection.
Infect Control Hosp Epidemiol.
2005;
26
196-203
-
51
Fagon J Y, Chastre J, Wolff M et al..
Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial.
Ann Intern Med.
2000;
132
621-630
-
52
Harbarth S, Dharan S, Liassine N, Herrault P, Auckenthaler R, Pittet D.
Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus
.
Antimicrob Agents Chemother.
1999;
43
1412-1416
-
53
Parras F, Guerrero M C, Bouza E et al..
Comparative study of mupirocin and oral co-trimoxazole plus topical fusidic acid in eradication of nasal carriage of methicillin-resistant Staphylococcus aureus
.
Antimicrob Agents Chemother.
1995;
39
175-179
-
54
Krueger W A, Lenhart F P, Neeser G et al..
Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial.
Am J Respir Crit Care Med.
2002;
166
1029-1037
-
55
de Jonge E, Schultz M J, Spanjaard L et al..
Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial.
Lancet.
2003;
362
1011-1016
-
56
de Jonge E.
Effects of selective decontamination of digestive tract on mortality and antibiotic resistance in the intensive-care unit.
Curr Opin Crit Care.
2005;
11
144-149
-
57
Verwaest C, Verhaegen J, Ferdinande P et al..
Randomized, controlled trial of selective digestive decontamination in 600 mechanically ventilated patients in a multidisciplinary intensive care unit.
Crit Care Med.
1997;
25
63-71
-
58
Leone M, Albanese J, Antonini F, Nguyen-Michel A, Martin C.
Long-term (6-year) effect of selective digestive decontamination on antimicrobial resistance in intensive care, multiple-trauma patients.
Crit Care Med.
2003;
31
2090-2095
-
59
Lingnau W, Berger J, Javorsky F, Fille M, Allerberger F, Benzer H.
Changing bacterial ecology during a five-year period of selective intestinal decontamination.
J Hosp Infect.
1998;
39
195-206
-
60
Silvestri L, Milanese M, Oblach L et al..
Enteral vancomycin to control methicillin-resistant Staphylococcus aureus outbreak in mechanically ventilated patients.
Am J Infect Control.
2002;
30
391-399
-
61
Bergmans D C, Bonten M J, Gaillard C A et al..
Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study.
Am J Respir Crit Care Med.
2001;
164
382-388
-
62
Pugin J, Auckenthaler R, Lew D P, Suter P M.
Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia: a randomized, placebo-controlled, double-blind clinical trial.
JAMA.
1991;
265
2704-2710
-
63
Silvestri L, van Saene H K, Milanese M et al..
Prevention of MRSA pneumonia by oral vancomycin decontamination: a randomised trial.
Eur Respir J.
2004;
23
921-926
-
64
Lindsay J A, Holden M T.
Staphylococcus aureus: superbug, super genome?.
Trends Microbiol.
2004;
12
378-385
-
65
Melles D C, Gorkink R F, Boelens H A et al..
Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus
.
J Clin Invest.
2004;
114
1732-1740
-
66
Feil E J, Cooper J E, Grundmann H et al..
How clonal is Staphylococcus aureus?
.
J Bacteriol.
2003;
185
3307-3316
-
67
Lowy F D.
Staphylococcus aureus infections.
N Engl J Med.
1998;
339
520-532
-
68
Fedtke I, Gotz F, Peschel A.
Bacterial evasion of innate host defenses: the Staphylococcus aureus lesson.
Int J Med Microbiol.
2004;
294
189-194
-
69
de Haas C J, Veldkamp K E, Peschel A et al..
Chemotaxis inhibitory protein of Staphylococcus aureus: a bacterial antiinflammatory agent.
J Exp Med.
2004;
199
687-695
-
70
Panton P NV.
FCO. Staphylococcal toxin.
Lancet.
1931;
1
506-508
-
71
Lina G, Piemont Y, Godail-Gamot F et al..
Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia.
Clin Infect Dis.
1999;
29
1128-1132
-
72
Francis J S, Doherty M C, Lopatin U et al..
Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes.
Clin Infect Dis.
2005;
40
100-107
-
73
Vandenesch F, Naimi T, Enright M C et al..
Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence.
Emerg Infect Dis.
2003;
9
978-984
-
74
Hiramatsu K.
Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance.
Lancet Infect Dis.
2001;
1
147-155
-
75
de Lencastre H, de Jonge B L, Matthews P R, Tomasz A.
Molecular aspects of methicillin resistance in Staphylococcus aureus
.
J Antimicrob Chemother.
1994;
33
7-24
-
76
Ma X X, Ito T, Tiensasitorn C et al..
Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains.
Antimicrob Agents Chemother.
2002;
46
1147-1152
-
77
Sakoulas G, Eliopoulos G M, Fowler Jr V G et al..
Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function.
Antimicrob Agents Chemother.
2005;
49
2687-2692
-
78
Moise-Broder P A, Sakoulas G, Eliopoulos G M, Schentag J J, Forrest A, Moellering Jr R C.
Accessory gene regulator group II polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy.
Clin Infect Dis.
2004;
38
1700-1705
-
79
Sakoulas G, Eliopoulos G M, Moellering Jr R C et al..
Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?.
J Infect Dis.
2003;
187
929-938
-
80
Fowler Jr V G, Sakoulas G, McIntyre L M et al..
Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein.
J Infect Dis.
2004;
190
1140-1149
-
81
Tomasz A, Drugeon H B, de Lencastre H M, Jabes D, McDougall L, Bille J.
New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity.
Antimicrob Agents Chemother.
1989;
33
1869-1874
-
81a
Hiramatsn K, Hanaki H, Ino T, Yabnta K, Oguri T, Tenover F C.
Methicillin-resistance Staphylococcus aureus clinical strain with reduced suscaptibility.
J Antimicrob Chemother.
1987;
40
135-136
-
82
Chang S, Sievert D M, Hageman J C et al..
Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene.
N Engl J Med.
2003;
348
1342-1347
-
83
Cosgrove S E, Carroll K C, Perl T M.
Staphylococcus aureus with reduced susceptibility to vancomycin.
Clin Infect Dis.
2004;
39
539-545
-
84
Fridkin S K, Hageman J, McDougal L K et al..
Epidemiological and microbiological characterization of infections caused by Staphylococcus aureus with reduced susceptibility to vancomycin, United States, 1997-2001.
Clin Infect Dis.
2003;
36
429-439
-
85
Sieradzki K, Roberts R B, Haber S W, Tomasz A.
The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection.
N Engl J Med.
1999;
340
517-523
-
86
Howe R A, Wootton M, Bennett P M, MacGowan A P, Walsh T R.
Interactions between methicillin and vancomycin in methicillin-resistant Staphylococcus aureus strains displaying different phenotypes of vancomycin susceptibility.
J Clin Microbiol.
1999;
37
3068-3071
-
87
Climo M W, Patron R L, Archer G L.
Combinations of vancomycin and beta-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin.
Antimicrob Agents Chemother.
1999;
43
1747-1753
-
88
Bozdogan B, Esel D, Whitener C, Browne F A, Appelbaum P C.
Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center.
J Antimicrob Chemother.
2003;
52
864-868
-
89
Handwerger S, Skoble J, Discotto L F, Pucci M J.
Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United States.
Antimicrob Agents Chemother.
1995;
39
362-368
-
90
Arthur M, Molinas C, Depardieu F, Courvalin P.
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.
J Bacteriol.
1993;
175
117-127
-
91
Arthur M, Courvalin P.
Genetics and mechanisms of glycopeptide resistance in enterococci.
Antimicrob Agents Chemother.
1993;
37
1563-1571
-
92
Leclercq R, Dutka-Malen S, Brisson-Noel A et al..
Resistance of enterococci to aminoglycosides and glycopeptides.
Clin Infect Dis.
1992;
15
495-501
-
93
Arthur M, Reynolds P E, Depardieu F et al..
Mechanisms of glycopeptide resistance in enterococci.
J Infect.
1996;
32
11-16
-
94
Evers S, Courvalin P.
Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR(B) two-component regulatory system in Enterococcus faecalis V583.
J Bacteriol.
1996;
178
1302-1309
-
95
Dutka-Malen S, Molinas C, Arthur M, Courvalin P.
Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance.
Gene.
1992;
112
53-58
-
96
Panesso D, Abadia-Patino L, Vanegas N, Reynolds P E, Courvalin P, Arias C A.
Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance.
Antimicrob Agents Chemother.
2005;
49
1060-1066
-
97
Billot-Klein D, Gutmann L, Sable S, Guittet E, van Heijenoort J.
Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum
.
J Bacteriol.
1994;
176
2398-2405
-
98
Moise P A, Forrest A, Bhavnani S M, Birmingham M C, Schentag J J.
Area under the inhibitory curve and a pneumonia scoring system for predicting outcomes of vancomycin therapy for respiratory infections by Staphylococcus aureus
.
Am J Health Syst Pharm.
2000;
57(Suppl 2)
S4-S9
-
99
Cui L, Ma X, Sato K et al..
Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus
.
J Clin Microbiol.
2003;
41
5-14
-
100
Levine D P, Fromm B S, Reddy B R.
Slow response to vancomycin or vancomycin plus rifampin in methicillin-resistant Staphylococcus aureus endocarditis.
Ann Intern Med.
1991;
115
674-680
-
101
Moise-Broder P A, Forrest A, Birmingham M C, Schentag J J.
Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections.
Clin Pharmacokinet.
2004;
43
925-942
-
102
Moise P A, Forrest A, Birmingham M C, Schentag J J.
The efficacy and safety of linezolid as treatment for Staphylococcus aureus infections in compassionate use patients who are intolerant of, or who have failed to respond to, vancomycin.
J Antimicrob Chemother.
2002;
50
1017-1026
-
103
Fagon J, Patrick H, Haas D W et al..
Treatment of gram-positive nosocomial pneumonia: prospective randomized comparison of quinupristin/dalfopristin versus vancomycin. Nosocomial Pneumonia Group.
Am J Respir Crit Care Med.
2000;
161
753-762
-
104
Rubinstein E, Cammarata S, Oliphant T, Wunderink R.
Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study.
Clin Infect Dis.
2001;
32
402-412
-
105
Baughman R P, Kerr M A.
Ventilator-associated pneumonia patients who do not reduce bacteria from the lungs have a worse prognosis.
J Intensive Care Med.
2003;
18
269-274
-
106
Cruciani M, Gatti G, Lazzarini L et al..
Penetration of vancomycin into human lung tissue.
J Antimicrob Chemother.
1996;
38
865-869
-
107
Lamer C, de Beco V, Soler P et al..
Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patients.
Antimicrob Agents Chemother.
1993;
37
281-286
-
108
Georges H, Leroy O, Alfandari S et al..
Pulmonary disposition of vancomycin in critically ill patients.
Eur J Clin Microbiol Infect Dis.
1997;
16
385-388
-
109
Sakoulas G, Moise-Broder P A, Schentag J, Forrest A, Moellering Jr R C, Eliopoulos G M.
Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia.
J Clin Microbiol.
2004;
42
2398-2402
-
110
Wysocki M, Delatour F, Faurisson F et al..
Continuous versus intermittent infusion of vancomycin in severe staphylococcal infections: prospective multicenter randomized study.
Antimicrob Agents Chemother.
2001;
45
2460-2467
-
111
Cepeda J A, Whitehouse T, Cooper B et al..
Linezolid versus teicoplanin in the treatment of gram-positive infections in the critically ill: a randomized, double-blind, multicentre study.
J Antimicrob Chemother.
2004;
53
345-355
-
112
Sgarabotto D, Cusinato R, Narne E et al..
Synercid plus vancomycin for the treatment of severe methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci infections: evaluation of 5 cases.
Scand J Infect Dis.
2002;
34
122-126
-
113
Anstead G M, Owens A D.
Recent advances in the treatment of infections due to resistant Staphylococcus aureus
.
Curr Opin Infect Dis.
2004;
17
549-555
-
114
Eliopoulos G M.
Quinupristin-dalfopristin and linezolid: evidence and opinion.
Clin Infect Dis.
2003;
36
473-481
-
115
Wunderink R G, Rello J, Cammarata S K, Croos-Dabrera R V, Kollef M H.
Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia.
Chest.
2003;
124
1789-1797
-
116
Kollef M H, Rello J, Cammarata S K, Croos-Dabrera R V, Wunderink R G.
Clinical cure and survival in gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin.
Intensive Care Med.
2004;
30
388-394
-
117
Stevens D L, Herr D, Lampiris H, Hunt J L, Batts D H, Hafkin B.
Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections.
Clin Infect Dis.
2002;
34
1481-1490
-
118
Gee T, Ellis R, Marshall G, Andrews J, Ashby J, Wise R.
Pharmacokinetics and tissue penetration of linezolid following multiple oral doses.
Antimicrob Agents Chemother.
2001;
45
1843-1846
-
119
Honeybourne D, Tobin C, Jevons G, Andrews J, Wise R.
Intrapulmonary penetration of linezolid.
J Antimicrob Chemother.
2003;
51
1431-1434
-
120
Conte Jr J E, Golden J A, Kipps J, Zurlinden E.
Intrapulmonary pharmacokinetics of linezolid.
Antimicrob Agents Chemother.
2002;
46
1475-1480
-
121
Boselli E, Breilh D, Rimmele T et al..
Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumonia.
Crit Care Med.
2005;
33
1529-1533
-
122
Bernardo K, Pakulat N, Fleer S et al..
Subinhibitory concentrations of linezolid reduce Staphylococcus aureus virulence factor expression.
Antimicrob Agents Chemother.
2004;
48
546-555
-
123
Ohlsen K, Ziebuhr W, Koller K P, Hell W, Wichelhaus T A, Hacker J.
Effects of subinhibitory concentrations of antibiotics on alpha-toxin (hla) gene expression of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates.
Antimicrob Agents Chemother.
1998;
42
2817-2823
-
124
Nasraway S A, Shorr A F, Kuter D J, O'Grady N, Le V H, Cammarata S K.
Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use.
Clin Infect Dis.
2003;
37
1609-1616
-
125
Shopsin B, Zhao X, Kreiswirth B N, Tillotson G S, Drlica K.
Are the new quinolones appropriate treatment for community-acquired methicillin-resistant Staphylococcus aureus?
.
Int J Antimicrob Agents.
2004;
24
32-34
-
126
Sander A, Beiderlinden M, Schmid E N, Peters J.
Clinical experience with quinupristin-dalfopristin as rescue treatment of critically ill patients infected with methicillin-resistant staphylococci.
Intensive Care Med.
2002;
28
1157-1160
-
127
Fenton C, Keating G M, Curran M P.
Daptomycin.
Drugs.
2004;
64
445-455
discussion 457-458
-
128
Zhanel G G, Homenuik K, Nichol K et al..
The glycylcyclines: a comparative review with the tetracyclines.
Drugs.
2004;
64
63-88
-
129
Van Bambeke F, Van Laethem Y, Courvalin P, Tulkens P M.
Glycopeptide antibiotics: from conventional molecules to new derivatives.
Drugs.
2004;
64
913-936
-
130
Tsiodras S, Gold H S, Sakoulas G et al..
Linezolid resistance in a clinical isolate of Staphylococcus aureus
.
Lancet.
2001;
358
207-208
Richard G WunderinkM.D.
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine
676 North St. Clair, Ste. 14-044, Chicago, IL 60611
Email: r-wunderink@northwestern.edu