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DOI: 10.1055/s-2006-924109
Georg Thieme Verlag KG Stuttgart · New York
Functional MRI Reveals Activation of a Subcortical Network in a 5-Year-Old Girl with Genetically Confirmed Myoclonus-Dystonia
Publication History
Received: February 6, 2006
Accepted after Revision: February 13, 2006
Publication Date:
14 June 2006 (online)
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Abstract
We investigated a five-year-old girl suffering from genetically confirmed, action-induced myoclonus-dystonia (M‐D) with functional magnetic resonance imaging (MRI). We compared the activation pattern by movements of her right hand as if drawing a picture, which elicited M‐D, with simple snapping movements (without overt M‐D). The drawing and snapping conditions resulted in activation of a motor network including the motor cortex, the putamen, and the cerebellar hemispheres. The direct comparison of the drawing condition with snapping as control revealed specific activations within the thalamus and the dentate nucleus. An age matched healthy control did not show significant activation within the thalamus or dentate nucleus.
Key words
Myoclonus-dystonia - dentate thalamus - fMRI
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PD Dr. Matthias F. Nitschke
Department of Neurology
University Hospital of Schleswig-Holstein
Campus Lübeck
Ratzeburger Allee 160
23538 Lübeck
Germany
Email: matthias.nitschke@neuro.uni-luebeck.de