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Synfacts 2006(1): 0055-0055
DOI: 10.1055/s-2005-921728
DOI: 10.1055/s-2005-921728
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Tantalum-Promoted Synthesis of α-Amino Amides from Imines and Isocyanates
H. Shimizu, S. Kobayashi*
The University of Tokyo, Japan
Further Information
Publication History
Publication Date:
16 December 2005 (online)
![](https://www.thieme-connect.de/media/synfacts/200601/lookinside/thumbnails/10.1055-s-2005-921728-1.jpg)
Significance
Amino acid derivatives are one of the most important classes of naturally occurring biologically active products. This is a new, original preparation of α-amino acid amides from imines and isocyanates, based on unusual organotantalum chemistry. The products are ‘drug-like’ molecules, which might be interesting for pharmaceutical research.