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Synfacts 2005(2): 0223-0223
DOI: 10.1055/s-2005-916075
DOI: 10.1055/s-2005-916075
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Catalytic Enantioselective Enolate Alkylations with Orthoesters
D. A. Evans*, R. J. Thomson
Harvard University, Cambridge, USA
Further Information
Publication History
Publication Date:
25 October 2005 (online)
![](https://www.thieme-connect.de/media/synfacts/200502/lookinside/thumbnails/10.1055-s-2005-916075-1.jpg)
Significance
Catalytic enantioselective methods for enolate alkylations have not been widely explored as of yet. This communication demonstrates an effective method for introducing an acetal functionality with high enantioselectivity. A wide variety of α-substituents are tolerated, with no detrimental effect towards enantioselectivity.