Planta Med 2006; 72(1): 52-59
DOI: 10.1055/s-2005-873190
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Five New Diels-Alder Type Adducts from the Stem and Root Bark of Morus mongolica

Jie Kang1 , Ruo-Yun Chen1 , De-Quan Yu1
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China
Further Information

Publication History

Received: March 31, 2005

Accepted: June 29, 2005

Publication Date:
10 November 2005 (online)

Abstract

Five new Diels-Alder type adducts, mongolicins A - E (1 - 5), and nine known compounds, mongolicin F (6), chalcomoracin (7), mulberrofuran T (8), mulberrofuran G (9), mulberrofuran F (10), albanol B (11), kuwanon O (12), mulberrofuran H (13) and kuwanon H (14), were isolated from the stem and root bark of Morus mongolica. Their structures were determined by spectroscopic analysis and chiroptical methods. Among them, compounds 3 and 5 showed potent anti-inflammatory activities (inhibition of release of β-glucuronidase from rat PMNs induced by PAF) with inhibitory ratios of 80.4 % (P < 0.05) and 77.0 % (P < 0.001) at a concentration of 10-5 mol L-1. Compounds 2, 6 and 12 were active as antioxidatives (inhibition of liver microsomal lipid peroxidation induced by Fe2+-Cys system) with inhibitory ratios of 83.6 % (P < 0.05), 86.0 % (P < 0.05), and 63.0 % (P < 0.05) at a concentration of 10-5 mol L-1.

References

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Prof. Ruo-yun Chen

Institute of Materia Medica

Chinese Academy of Medical Sciences and Peking Union Medical College

1 Xian Nong Tan Street

Beijing 100050

People’s Republic of China

Fax: +86-010-6301-7757

Email: ruoyunchen@hotmail.com