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Synfacts 2005(1): 0168-0168
DOI: 10.1055/s-2005-872221
DOI: 10.1055/s-2005-872221
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
The First Solid-Phase Synthesis of Bis(oxazolinyl)pyridine Ligands
A. Weisberg, B. Halak, M. Portnoy*
Tel-Aviv University, Israel
Further Information
Publication History
Publication Date:
21 September 2005 (online)
Significance
The solid-phase synthesis of bis(oxazolinyl)pyridine ligand (Pybox) on Wang resin was described. The pybox ligands (1a-g) were prepared in 66-90% yield. Tertiary Bu-Pybox 1f showed high enantioselectivity for copper-catalyzed asymmetric alkylation of benzylideneaniline with phenylacetylene (83% ee, 63% yield).