Synthesis of ABT-100, a Farnesyl Transferase Inhibitor

M. J. Rozema; A. W. Kruger; B. D. Rohde; B. Shelat; L. Bhagavatula; J. J. Tien; W. Zhang; R. F. Henry

doi:10.1055/s-2005-872147

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Synfacts 2005(1): 0100-0100
DOI: 10.1055/s-2005-872147

Synthesis of Natural Products and Potential Drugs

Synthesis of ABT-100, a Farnesyl Transferase Inhibitor

Contributor(s): Philip Kocienski
M. J. Rozema*, A. W. Kruger, B. D. Rohde, B. Shelat, L. Bhagavatula, J. J. Tien, W. Zhang, R. F. Henry
Abbott Laboratories, North Chicago, USA

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Publication History

Publication Date:
21 September 2005 (online)

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Significance

The target molecule inhibits farnesyl transferase, an enzyme required for ras-protein activation that drives uncontrolled cell proliferation in some cancers.