Planta Med 2005; 71(7): 659-665
DOI: 10.1055/s-2005-871273
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Biflavonoids from Selaginella delicatula

Jih-Jung Chen1 , Chang-Yih Duh2 , Jinn-Fen Chen3
  • 1Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
  • 2Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China
  • 3Taitung District Agricultural Research and Extension Station, Taitung, Taiwan, Republic of China
Further Information

Publication History

Received: September 6, 2004

Accepted: February 14, 2005

Publication Date:
18 July 2005 (online)

Abstract

Five new biflavonoids, robustaflavone 7,4′,4′′′-trimethyl ether, robustaflavone 4′,4′′′-dimethyl ether, 2,3-dihydroamentoflavone 7,4′,7′′-trimethyl ether, 2,3-dihydroamentoflavone 7,4′-dimethyl ether, and 2′′,3′′-dihydroisocryptomerin 7-methyl ether, together with six known compounds have been isolated from the aerial parts of Selaginella delicatula. The structures of these new compounds were determined through spectral analyses. Among the isolates, robustaflavone 4′,4′′′-dimethyl ether, 2,3-dihydroamentoflavone 7,4′-dimethyl ether, and α-tocopheryl quinone exhibited cytotoxicities (ED50 values < 4 μg/mL) against P-388 and/or HT-29 cell lines in vitro.

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Dr. J. J. Chen

Department of Pharmacy

Tajen Institute of Technology

Pingtung

Taiwan 907

Republic of China

Phone: +886-8-762-4002 ext 332

Fax: +886-8-762-5308

Email: jjchen@ccsun.tajen.edu.tw