Semin Reprod Med 2004; 22(1): 25-30
DOI: 10.1055/s-2004-823024
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Models of Aromatase Insufficiency

Evan R. Simpson1
  • 1Prince Henry's Institute of Medical Research and the Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
Further Information

Publication History

Publication Date:
13 April 2004 (online)

The recent studies on humans with a defective gene that encodes aromatase P450 (P450arom) and aromatase knockout (ArKO) mice with a disrupted P450arom gene uncovered many interesting aspects of physiology. Aromatase-deficient humans and ArKO mice continue to serve as invaluable models for us to study the roles of estrogen in normal and abnormal functions of several tissues. These roles will be discussed in detail in the following review article.

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 Professor
Evan R Simpson

Monash Medical Centre, Level 4, Block E, Prince Henry's Institute of Medical Research

P.O. Box 5152, 246 Clayton Road

Clayton, Victoria 3168 Australia