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DOI: 10.1055/s-2003-38486
© Georg Thieme Verlag Stuttgart · New York
Antitumor Activity of Flavones Isolated from Artemisia argyi
Publication History
Received: July 15, 2002
Accepted: November 23, 2002
Publication Date:
04 April 2003 (online)
![](https://www.thieme-connect.de/media/plantamedica/200303/lookinside/thumbnails/10.1055-s-2003-38486-1.jpg)
Abstract
The flavones 5,6-dihydroxy-7,3′,4′-trimethoxyflavone (1), 5,6,4′-trihydroxy-7,3′-dimethoxyflavone (2), 5-hydroxy-3′,4′,6,7-tetramethoxyflavone, 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone, ladanein, and hispidulin were isolated from the methanolic extracts of the aerial parts of Artemisia argyi and structures of the compounds were elucidated on the basis of their spectral data. These flavones inhibited farnesyl protein transferase with IC50 values of 25 - 200 μg/mL. Compound 2 inhibited proliferation of a couple of tumor cell lines and also inhibited neovascularization in a chick chorioallantoic membrane assay. Without loss of body weight of nude mice, compounds 1 and 2 inhibited growth of a colon tumor (SW620) by 44.6 % and 14.6 %, respectively.
Abbreviations
FPTase:farnesyl protein transferase
CAM:chick embryo chorioallantoic membrane
Key words
Artemisia argyi - Compositae - Flavones - Farnesyl protein transferase - Angiogenesis
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Dr. Byoung-Mog Kwon
Korea Research Institute of Bioscience and Biotechnology
52 Uendong
Yusunggu
Taejon 305-600
Republic of Korea
Phone: +82-42-860-4557
Fax: +82-42-861-2675
Email: kwonbm@kribb.re.kr