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Seminars in Neurosurgery 2002; 13(2): 131-144
DOI: 10.1055/s-2002-35810
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Inflammatory Conditions of the Craniocervical Junction

Sagun Tuli, Eric J. Woodard
  • Division of Spinal Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
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Publikationsverlauf

Publikationsdatum:
28. November 2002 (online)

    Lizenzen und Reprints

ABSTRACT

Inflammatory conditions at the craniocervical junction (CCJ) consist mainly of rheumatic diseases and spondyloarthropathies, with rheumatoid arthritis (RA) representing the predominant example of the former condition. Secondary atlantoaxial subluxation (AAS) is noted in up to 70% of cases of RA, yet neurologic manifestations are not common. Atlantoaxial impaction (AAI) however, a less frequent entity, is associated with potentially grave deficits. All of the seronegative spondyloarthropathies may also have abnormalities at the CCJ.

Erosive inflammatory changes in the synovium cause damage and subsequent loss of the adjacent ligament, cartilage, and bone, producing typical radiological features. As the disease progresses there is worsening instability, yet a corresponding rate of neurologic compromise is not seen. The life span for patients with RA is approximately 65 years, with mortality being highest in myelopathic patients.

Radiological investigations include plain radiographs, computed tomographic scans, and magnetic resonance imaging (MRI). The plain films are frequently used for screening, with the posterior atlantodental interval (PADI) being most predictive of paralysis from AAS. The Clark's station, the Ranawat criterion, and the Redlund-Johnell criteria are useful for predicting AAI. MRI currently is most effective for defining CCJ relationships.

Clinical manifestations of CCJ pathology occur because of direct compression by bone/soft tissue and/or from vertebral or anterior spinal artery compromise. The Ranawat grading scale is the most universally accepted scale for functional assessment. Prognostic severity criteria for AAS and AAI are the degree of peripheral joint disease, duration of RA, seropositivity, male gender, presence of rheumatoid nodules, and use of corticosteroids.

Treatment for RA, either conservative or surgical, is controversial. Intractable neck pain and neurologic deficits are well-accepted indications for surgery. In asymptomatic patients the role of surgery is based on a variety of radiologic criteria for instability.

KEYWORDS

Craniocervical junction - inflammatory conditions - rheumatoid arthritis - spondyloarthropathies

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