Am J Perinatol 2002; 19(6): 285-290
DOI: 10.1055/s-2002-34466
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

CT Imaging of Pulmonary Lobar Interstitial Emphysema in a Spontaneous Breathing Preterm Infant

J. Dembinski1 , A. Heep1 , N. Kau1 , G. Knöpfle2 , P. Bartmann1
  • 1Department of Neonatology, Center of Pediatrics, University of Bonn, Germany
  • 2Department of Pathology, University of Bonn, Germany
Further Information

Publication History

Publication Date:
01 October 2002 (online)

ABSTRACT

Pulmonary interstitial emphysema (PIE) is a well-recognized severe complication of neonatal respiratory distress syndrome (RDS). However, its occurence under spontaneous breathing conditions has been described rarely. We present a case of PIE of the left upper lung lobe in an extremely low birth weight infant. Recurrent episodes of spontaneous pneumothorax led to the diagnosis, which was confirmed by histopathology. Plain chest X-ray did not show typical signs of PIE, whereas extra-alveolar air accumulation could be visualized by helical computed tomography (CT)-scan. We stress the role of predispositional factors increasing the risk of PIE development in spontaneous breathing preterm infants.

REFERENCES

  • 1 Campbell R E. Intrapulmonary interstitial emphysema: a complication of hyaline membrane disease.  Am J Roentgenol Radium Ther Nucl Med . 1970;  110 449-456
  • 2 Cochran D P, Pilling D W, Shaw N J. The relationship of pulmonary interstitial emphysema to subsequent type of chronic lung disease.  Br J Radiol . 1994;  67 1155-1157
  • 3 Yost C C, Soll R F. Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome.  Cochrane Database Syst Rev 2000;CD001456.
  • 4 Todd D A, Jana A, John E. Chronic oxygen dependency in infants born at 24-32 weeks' gestation: the role of antenatal and neonatal factors.  J Paediatr Child Health . 1997;  33 402-407
  • 5 Willet K E, Jobe A H, Ikegami M, Newnham J, Sly P D. Pulmonary interstitial emphysema 24 hours after antenatal betamethasone treatment in preterm sheep.  Am J Respir Crit Care Med . 2000;  162 1087-1094
  • 6 Smith T H, Currarino G, Rutledge J C. Spontaneous occurrence of localized pulmonary interstitial and endolymphatic emphysema in infancy.  Pediatr Radiol . 1984;  14 142-145
  • 7 Yu V Y, Liew S W, Robertson N R. Pneumothorax in the newborn: changing pattern.  Arch Dis Child . 1975;  50 449-453
  • 8 Coradello H, Fodor M, Simbruner G. Intrapulmonary interstitial emphysema in ventilatory supported infants.  Klin Padiatr . 1980;  192 408-414
  • 9 Yu V Y, Wong P Y, Bajuk B, Szymonowicz W. Pulmonary interstitial emphysema in infants less than 1000 g at birth.  Aust Paediatr J . 1986;  22 189-192
  • 10 Chernick V, Avery M E. Spontaneous alveolar rupture at birth.  Pediatrics . 1963;  32 816
  • 11 Gould S. The respiratory system: developmental abnormalities. In: Keeling JW, ed. Fetal and Neonatal Pathology 2nd ed. London: Springer 1993: 403-428
  • 12 Cohen M C, Drut R M, Drut R. Solitary unilocular cyst of the lung with features of persistent interstitial pulmonary emphysema: report of four cases.  Pediatr Dev Pathol . 1999;  2 531-536
  • 13 Bancalari E, Hodson A. Normal and abnormal structural development of the lung. In: Polin RA, Fox WW, eds. Fetal and Neonatal Physiology 2nd ed. Philadelphia: WB Saunders 1998: 1033-1046
  • 14 Lanteri C J, Willet K E, Kano S. Time course of changes in lung mechanics following fetal steroid treatment.  Am J Respir Crit Care Med . 1994;  150 759-765
  • 15 Willet K E, Gurrin L, Burton P. Differing patterns of mechanical response to direct fetal hormone treatment.  Respir Physiol . 1996;  103 271-280
  • 16 Kemper A C, Steinberg K P, Stern E J. Pulmonary interstitial emphysema: CT findings.  Am J Roentgenol . 1999;  172 1642
  • 17 Jabra A A, Fishman E K, Shehata B M, Perlman E J. Localized persistent pulmonary interstitial emphysema: CT findings with radiographic-pathologic correlation.  Am J Roentgenol . 1997;  169 1381-1384
  • 18 Cox T D, White K S, Weinberger E, Effmann E L. Comparison of helical and conventional chest CT in the uncooperative pediatric patient.  Pediatr Radiol . 1995;  25 347-349
  • 19 Mooney D P, Sargent S K, Pluta D, Mazurek P. Spiral CT: use in the evaluation of chest masses in the critically ill neonate.  Pediatr Radiol . 1996;  26 15-18
  • 20 O'Donovan D, Wearden M, Adams J. Unilateral pulmonary interstitial emphysema following pneumonia in a preterm infant successfully treated with prolonged selective bronchial intubation.  Am J Perinatol . 1999;  16 327-331
  • 21 Cohen R S, Smith D W, Stevenson D K, Moskowitz P S, Graham C B. Lateral decubitus position as therapy for persistent focal pulmonary interstitial emphysema in neonates: a preliminary report.  J Pediatr . 1984;  104 441-443
  • 22 Miyahara K, Ichihara T, Watanabe T. Successful use of high frequency oscillatory ventilation for pneumomediastinum.  Ann Thorac Cardiovasc Surg . 1999;  5 49-51
  • 23 Helbich T H, Popow C, Dobner M, Wunderbaldinger P, Zekert M, Herold C J. New-born infants with severe hyaline membrane disease: radiological evaluation during high frequency oscillatory versus conventional ventilation.  Eur J Radiol . 1998;  28 243-249
  • 24 Nelle M, Zilow E P, Linderkamp O. Effects of high-frequency oscillatory ventilation on circulation in neonates with pulmonary interstitial emphysema or RDS.  Intensive Care Med . 1997;  23 671-676
  • 25 Kohlhauser C, Popow C, Helbich T, Hermon M, Weninger M, Herold C J. Successful treatment of severe neonatal lobar emphysema by high-frequency oscillatory ventilation.  Pediatr Pulmonol . 1995;  19 52-55
  • 26 Rettwitz-Volk W, Fischer D, Schlosser R L, Allendorf A, von Loewenich V. High-frequency oscillating ventilation in premature infants under 1500 gram birth weight.  Klin Padiatr . 1994;  206 414-420
  • 27 Varnholt V, Lasch P, Kachel W, Diehm T, Koelfen W. High frequency oscillatory ventilation of infants with severe respiratory disorders: possibilities, risks and limits.  Klin Padiatr . 1994;  206 161-166
  • 28 HiFO Study Group. Randomized study of high-frequency oscillatory ventilation in infants with severe respiratory distress syndrome.  J Pediatr . 1993;  122 609-619
  • 29 Bhuta T, Henderson-Smart D J. Elective high-frequency oscillatory ventilation versus conventional ventilation in preterm infants with pulmonary dysfunction: systematic review and meta-analyses.  Pediatrics . 1997;  100 E6
  • 30 The HIFI Study Group. High-frequency oscillatory ventilation compared with conventional mechanical ventilation in the treatment of respiratory failure in preterm infants.  N Engl J Med . 1989;  320 88-93
  • 31 Plavka R, Kopecky P, Sebron V, Svihovec P, Zlatohlavkova B, Janus V. A prospective randomized comparison of conventional mechanical ventilation and very early high frequency oscillatory ventilation in extremely premature newborns with respiratory distress syndrome.  Intensive Care Med . 1999;  25 68-75
    >