Substituted Pyridylamide Ligands in Microwave-Accelerated
Mo(0)-Catalysed Allylic Alkylations

Abstract

Novel 4- and 6-substituted bis-pyridylamides were prepared by microwave accelerated nucleophilic substitution of the 4- and 6-halo substituted derivatives of the parent ligand 1a. The ligands were used in the asymmetric allylation of cinnamyl carbonate catalysed by Mo(0) in which the 4-chloro- and 4-pyrrolidyl substituted ligand derivatives exhibited high regioselectivity (74:1 and 88:1, respectively) and enantioselectivity (96% ee), whereas 6-substituted ligands afforded no product under the same conditions. Other allylic substrates were used to explore the generality of the procedure.

Key words

molybdenum - allylations - asymmetric catalysis - pyr­idylamides - microwaves

References

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Belda, O.; Moberg, C., manuscript under preparation.