Planta Med 2002; 68(6): 519-522
DOI: 10.1055/s-2002-32554
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Flavonoids with Activity against Methicillin-Resistant Staphylococcus aureus from Dalea scandens var. paucifolia

N. P. Dhammika Nanayakkara, Charles L. Burandt Jr., Melissa R. Jacob
  • 1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA
Further Information

Publication History

August 24, 2001

December 16, 2001

Publication Date:
01 July 2002 (online)

Abstract

Bioassay-guided fractionation of the ethyl acetate extract of the roots of Dalea scandens (Miller) R. Clausen var. paucifolia led to the isolation of new flavonoids, 2(S)-5′-(-1′″,1″′-dimethylallyl)-8-(3″,3″-dimethylallyl)-2′,4′,5,7-tetrahydroxyflavanone, 2(S)-5′-(1″′,1″′-dimethylallyl)-8-(3″,3″-dimethylallyl)-2′-methoxy-4′,5,7-trihydroxyflavanone and 5′-(1″′,1″′-dimethylallyl)-8-(3″,3″-dimethylallyl)-2′,4′,5,7-tetrahydroxyflavone. Structure elucidation was carried out by spectroscopic methods. All three compounds showed significant activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus.

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N. P. Dhammika Nanayakkara

National Center for Natural Products Research

School of Pharmacy


The University of Mississippi

University

MS 38677, USA

Fax: +1-662-915-7989

Email: dhammika@olemiss.edu