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DOI: 10.1055/s-2001-17860
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662
Factors Predicting Compliance with Palivizumab in High-Risk Infants
Publikationsverlauf
Publikationsdatum:
17. Oktober 2001 (online)
ABSTRACT
Palivizumab must be administered monthly by intramuscular injection throughout the RSV season to maintain the serum concentration at a level sufficient to provide protection against respiratory syncytial virus (RSV). The objective of this study is to determine factors associated with completing all doses of palivizumab. The method was a survey mailed to the families of 385 high-risk children who were eligible to receive palivizumab at Columbus Children's Hospital in 1998-1999. Seventy-eight percent of eligible children received all doses of palivizumab. The strongest predictor of compliance was parents' perception that palivizumab would protect their child from RSV; 67% of parents in the compliant group reported they believed palivizumab protected their child ``a great deal'' against RSV compared with 48% in the noncompliant group (p = 0.04). Difficulty with transportation was also a barrier to compliance; 85% of parents in the compliant group reported no difficulty with transportation compared with 65% in the non-compliant group (p = 0.004). An interaction between Medicaid status and parental worry showed that parents whose child received Medicaid and who worried a lot (about their child getting RSV) were more likely to be compliant (Odds ratio = 6.62, p = 0.03). Communication with parents that focuses on the benefit of palivizumab in reducing RSV-associated illness and hospitalizations may increase compliance.
KEYWORD
Compliance - premature - low birth weight - respiratory syncytial virus - prevention