Dementia und SuicideB. Schneider, K. Maurer, L. Fröhlich
Zentrum der Psychiatrie, Klinik für Psychiatrie und Psychotherapie I (Direktor: Prof. Dr. K. Maurer), Johann Wolfgang Goethe-Universität, Frankfurt/Main
Obwohl sowohl dementielle Erkrankungen als auch Suizide mit zunehmendem Alter häufiger vorkommen, ist bisher der Zusammenhang zwischen Demenz und suizidalem Verhalten kaum systematisch untersucht worden. In den Studien zur Mortalität bei Demenzen findet sich - im Gegensatz zu den meisten psychiatrischen Erkrankungen - kein erhöhtes Suizidrisiko gegenüber der Allgemeinbevölkerung (SMR =0). Somit ist eine Erhöhung des Suizidrisikos im Alter durch dementielle Erkrankungen nicht gegeben. Auch in Untersuchungen mit der Methode der „psychological autopsy” wurden kaum dementielle Erkrankungen bei Suizidopfern diagnostiziert. In Verlaufsstudien werden bei weniger als 1 % aller Patienten mit Demenz Suizidversuche beobachtet. Depression als wichtiger gemeinsamer Risikofaktor für Suizid und Demenz kommt häufig zusammen mit Demenz vom Alzheimer Typ (Prävalenz zwischen 0 % und 86 %) als auch zusammen mit Multiinfarktdemenz vor (20 % bis 45 %), wobei jedoch Major Depression signifikant häufiger bei vaskulärer Demenz als bei Alzheimer Demenz auftreten soll. Suizidabsichten und -gedanken, Todeswünsche und lebensüberdrüssige Gedanken wurden bei 1 % bis 42 % aller Patienten mit dementiellen Erkrankungen berichtet und kommen vor allem bei gleichzeitigem Vorhandensein einer Depression vor. Bisher nicht systematisch untersuchte Zusammenhänge zwischen kognitiven Defiziten, Einsicht in die Erkrankung bei beginnender Demenz und Suizidalität sowie mögliche Interaktionseffekte werden in dieser Übersichtsarbeit umfassend diskutiert.
Dementia und Suicide:
The relationship between suicide and dementia has not systematically been investigated, although the prevalence of both, dementia and suicide, increases with age. In contrast to patients with other psychiatric disorders, patients with dementia were not found to die from suicide more often than expected (SMR, 0). Thus the diagnosis of dementia does not contribute to the elevated suicide risk in old age. In studies using the psychological autopsy method, dementia was rarely diagnosed in suicide victims. Suicide attempts were observed in less than 1 % of all patients with dementia. Depression as an important common risk factor of suicide and dementia is often found in patients with Alzheimer's disease (0 % to 86 %) as well as in patients with multi-infarct dementia (20 % to 45 %). However major depression was found significantly more often in vascular dementia than in dementia of Alzheimer type. Suicidal thoughts and intents, wishes to die and feelings that life is not worth living were reported in 1 % to 42 % of all patients with dementia, especially if these patients also suffered from depression. This review comprehensively presents the association between cognitive deficits, insight in early stages of dementia and suicidality and possible confounders which have not systematically been investigated up to now.
Literatur
1
Weissman M M, Leaf P J, Tischler G L, Blazer D G, Karno M, Bruce M L, Florio L P.
Affective disorders in five United States communities.
Psychol Med.
1988;
18
141-153
2
Vogel R, Wolfersdorf M.
Zum Verhältnis zwischen Suizid und psychischer Erkrankung im höheren Lebensalter.
Zeitschrift für Gerontologie.
1989;
22
242-246
3
Skoog I, Nilsson L, Palmertz B, Andreasson L A, Svanborg A.
A population-based study of dementia in 85-year-olds.
The New England Journal of Medicine.
1993;
328
153-158
5
Witthaus E, Ott A, Barendregt J J, Breteler M, Bonneux L.
Burden of mortality and morbidity from dementia.
Alzheimer Dis Assoc Disord.
1999;
13
176-181
6
Boersma F, van den Brink W, Deeg D J, Eefsting J A, van Tilburg W.
Survival in a population-based cohort of dementia patients: predictors and causes of mortality.
Int J Geriatr Psychiatry.
1999;
14
748-753
7
Aguero-Torres H, Fratiglioni L, Guo Z, Viitanen M, Winblad B.
Mortality from dementia in advanced age: a 5-year follow-up study of incident dementia cases.
J Clin Epidemiol.
1999;
52
737-743
10
Mölsä P K, Marttila R J, Rinne U K.
Long-term survival and predictors of mortality in Alzheimer's disease and multi-infarct dementia.
Arch Neurol Scand.
1995;
91
159-164
11
Kukull W A, Brenner D E, Speck C E, Nochlin D, Bowen J, McCornick W, Teri L, Pfanschmidt M L, Larson E B.
Causes of death associated with Alzheimer's disease: Variation by level of cognitive impairment before death.
J Am Geriatr Soc.
1994;
42
723-726
13
Heyman A, Peterson B, Fillenbaum G, Pieper C.
Predictors of time to institutionalization of patients with Alzheimer's disease: The CERAD xperience, part XVII.
Neurology.
1997;
48
1304-1349
14
Knopman D S, Kitto J, Deinard S, Heiring J.
Longitudinal study of death and institutionalization in patients with primary degenerative dementia.
J Am Geriatr Soc.
1988;
36
108-112
15
Mölsä P K, Marttila R J, Rinne U K.
Survival and cause of death in Alzheimer's disease and multi-infarct dementia.
Acta Neurol Scand.
1986;
74
103-107
17
Zubenko G S, Ulsant B H, Sweet R A, Pasternak R E, Tu X M.
Mortality of elderly patients with psychiatric disorders.
Am J Psychiatry.
1997;
154
1360-1368
18
Ferris S H, Hofeldt G T, Carbone G, Masciandaro P, Troetel W M, Imbimbo B P.
Suicide in two patients with diagnosis of probable Alzheimer disease.
Alzheimer Disease and Associated Disorders.
1999;
13
88-90
25
Black D W, Warrack B, Winokur G.
The Iowa record-linkage study II: excess mortality among patients with organic mental disorders.
Arch Gen Psychiatry.
1985;
42
78-81
36
Conwell Y, Duberstein P R, Cox C, Herrmann J H, Forbes N T, Caine E D.
Relationships of age and axis I diagnoses in victims of completed suicide: a psychological autopsy study.
Am J Psychiatry.
1996;
153
1001-1008
37 Barraclough B. Suicide in the elderly. In: Kay DM, Walk A (Hrsg) Recent Developments in Psychogeriatrics London: Royal Medico-Psychological Association 1971
38
Henriksson M M, Aro H M, Marttunen M J, Heikkinen M E, Isometsä E T, Kuoppasalmi J I, Lönnqvist J K.
Mental disorders and comorbidity in suicide.
Am J Psychiatry.
1993;
150
935-940
46
Henriksson M M, Marttunen M J, Isometsä E T, Aro H M, Kuoppasalmi J I, Lönnqvist J K.
Mental disorders in elderly suicide.
International Psychogeriatrics.
1995;
7
275-286
50
Beautrais A L, Joyce P R, Mulder R T, Fergusson D M, Deavoll B J, Nightingale S K.
Prevalence and comorbidity of mental disorders in persons makings serious suicide attempts: a case-control study.
Am J Psychiatry.
1996;
153
1009-1014
52
Upadhyaya A K, Warbuton H, Jenkins J C.
Psychiatric correlates of non-fatal deliberate self-harm in the elderly.
J Clin Exp Gerontol.
1989;
11
131-143
53
Takahashi Y, Hirasawa H, Koyama K, Asakawa O, Kido M, Onose H, Udagawa M, Ishikawa Y, Uno M.
Suicide an Aging in Japan: an examination of treated elderly suicide attempters.
International Psychogeriatrics.
1995;
7
239-251
54
Schmid H, Manjee K, Shah T.
On the distinction of suicide ideation versus attempt in elderly psychiatric inpatients.
Gerontologist.
1994;
34
332-339
55
Chiu H FK, Lam L CW, Pang A HT, Leung C M, Wong C K.
Attempted suicide by Chinese elderly in Hong Kong.
General Hospital Psychiatry.
1996;
18
444-447
59
Tariot P N, Mack J L, Patterson M B, Edland S D, Weiner M F, Fillenbaum G, Blazina L, Teri L, Rubin E, Mortimer J A, Stern Y.
The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavior Rating Scale for Dementia of the Consortium to establish a registry for Alzheimer's Disease.
Am J Psychiatry.
1995;
152
1349-1357
60
Draper B, MacCuspie-Moore C, Brodaty H.
Suicidal ideation and the “wish to die” in dementia patients: the role of depression.
Age and Ageing.
1998;
27
503-507
65
Teri L, Truax P, Logsdon R, Uomoto J, Zarit S, Vitaliano P P.
Assessment of behavioral problems in dementia: the revised memory and behavior checklist.
Psychol Aging.
1992;
7
622-631
68
Kishi Y, Robinson R G, Kosier J T.
Suicidal plans in patients with stroke: comparison between acute-onset and delayed onset suicidal plans.
International Psychogeriatrics.
1996;
8
623-634
69
Harwood D G, Ownby R L, Barker W W, Duara R.
The factor structure of the Cornell Scale for Depression in dementia among probable Alzheimer's disease patients.
Am J Geriatr Psychiatry.
1998;
6
212-220
70
Ballard C, Bannister C, Solis M, Oyebode F, Wilcock G.
The prevalence, associations and symptoms of depression amongst dementia sufferers.
J Affect Disord.
1996;
36
135-144
71
Feher E P, Mahurin R K, Inbody S B, Crook T H, Pirozzolo F J.
Anosognosia in Alzheimer's Disease.
Neuropsychiatr Neuropsychol Behav Neurol.
1991;
4
136-146
74
Upadhyaya A K, Conwell Y, Duberstein P R, Denning D, Cox C.
Attempted suicide in older depressed patients. Effect of cognitive functioning.
Am J Geriatr Psychiatry.
1999;
7
317-320
82
Keonig H G, Wildman-Hanlon D, Schmader K.
Attitudes of elderly patients and their families toward physician-assisted suicide.
Arch Intern Med.
1996;
156
2240-2248
83
Seidlitz L, Duberstein P R, Cox C, Conwell Y.
Attidues of older people toward suicide and assisted suicide. An analysis of Gallup Poll findings.
J Am Geriatr Soc.
1995;
43
993-998