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Clin Colon Rectal Surg
DOI: 10.1055/s-0044-1791521
Review Article

The Emerging Role of the Microbiota and Antibiotics in Diverticulitis Treatment

Alexander Troester   *
1   Department of Surgery, University of Minnesota, Minneapolis, Minnesota
,
Lauren Weaver   *
1   Department of Surgery, University of Minnesota, Minneapolis, Minnesota
,
Cyrus Jahansouz
2   Division of Colon & Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota
› Author Affiliations Funding None.
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Abstract

Diverticular disease is the leading cause of elective colon surgery. With a rising incidence in younger populations, it continues to pose a significant burden on the health care system. Traditional etiopathogenesis implicated an infectious mechanism, while recent challenges to this theory have demonstrated the microbiome playing a significant role, along with genetic predispositions and associations with obesity and diet. Therefore, the role of antibiotics in uncomplicated disease merits reconsideration. In this review, we aim to outline the current knowledge regarding antibiotics for diverticulitis treatment, broadly define the microbiome components, functions, and modifiability, and discuss newly proposed pathogenetic mechanisms for diverticular disease that incorporate information regarding the microbiome. Analytic techniques for microbiota characterization and function continue to advance at a rapid pace. As emerging technology advances, we will continue to elucidate the role of the microbiome in diverticular disease development.

Keywords

microbiome - antibiotics - diverticulitis - pathogenesis - treatment

Authors' Contributions

A. T. contributed to the project conception and design, as well as the drafting and editing of the manuscript. L. W. was involved in the project conception and design, along with drafting and editing the manuscript. C. J. participated in editing the manuscript and provided final approval.


* A. T. and L. W. equally contributed to this work.




Publication History

Article published online:
30 September 2024

© 2024. Thieme. All rights reserved.

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