Subscribe to RSS
DOI: 10.1055/s-0044-1788558
Radiographic Diagnosis of Osteoporotic Vertebral Fracture in Older Women and Men Based on Statistical Probability
Abstract
A radiographic gold standard to distinguish osteoporotic vertebral fractures (VFs) from nonosteoporotic VFs does not exist. Radiographic fracture-shaped vertebral deformity (FSVD) is common among young populations with normal bone strength. FSVD in an older population is called osteoporotic-like vertebral fracture (OLVF) when the FSVD is likely associated with compromised bone strength. For more severe grade deformities or when a vertebra is collapsed, experienced readers can make an osteoporotic VF diagnosis with a high degree of certainty. In milder cases, radiographic osteoporotic VF is often diagnosed based on a high probability rather than an absolute diagnosis. For older women, three nonadjacent minimal grade OLVFs (< 20% height loss), one minimal grade OLVF and one mild OLVF (≥ 20∼25% height loss), or one OLVF with ≥ 25% height loss meets the diagnosis of osteoporosis. For older men, a single OLVF with ≥ 33 to 40% height loss is insufficient to suggest the patient has osteoporosis.
Publication History
Article published online:
15 October 2024
© 2024. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Schwartz EN, Steinberg D. Detection of vertebral fractures. Curr Osteoporos Rep 2005; 3 (04) 126-135
- 2 Chou SH, Vokes T. Vertebral morphometry. J Clin Densitom 2016; 19 (01) 48-53
- 3 Wáng YXJ, Che-Nordin N, Deng M. et al. Osteoporotic vertebral deformity with endplate/cortex fracture is associated with higher further vertebral fracture risk: the Ms. OS (Hong Kong) study results. Osteoporos Int 2019; 30 (04) 897-905
- 4 Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 1993; 8 (09) 1137-1148
- 5 Lunt M, O'Neill TW, Felsenberg D. et al; European Prospective Osteoporosis Study Group. Characteristics of a prevalent vertebral deformity predict subsequent vertebral fracture: results from the European Prospective Osteoporosis Study (EPOS). Bone 2003; 33 (04) 505-513
- 6 Lentle BC, Berger C, Brown JP. et al. Vertebral fractures: which radiological criteria are better associated with the clinical course of osteoporosis?. Can Assoc Radiol J 2021; 72 (01) 150-158
- 7 Matsumoto M, Okada E, Kaneko Y. et al. Wedging of vertebral bodies at the thoracolumbar junction in asymptomatic healthy subjects on magnetic resonance imaging. Surg Radiol Anat 2011; 33 (03) 223-228
- 8 Gaca AM, Barnhart HX, Bisset III GS. Evaluation of wedging of lower thoracic and upper lumbar vertebral bodies in the pediatric population. AJR Am J Roentgenol 2010; 194 (02) 516-520
- 9 Abdel-Hamid Osman A, Bassiouni H, Koutri R, Nijs J, Geusens P, Dequeker J. Aging of the thoracic spine: distinction between wedging in osteoarthritis and fracture in osteoporosis—a cross-sectional and longitudinal study. Bone 1994; 15 (04) 437-442
- 10 Ismail AA, O'Neill TW, Cooper C, Silman AJ. European Vertebral Osteoporosis Study Group. Risk factors for vertebral deformities in men: relationship to number of vertebral deformities. J Bone Miner Res 2000; 15 (02) 278-283
- 11 Jackson SA, Tenenhouse A, Robertson L. Vertebral fracture definition from population-based data: preliminary results from the Canadian Multicenter Osteoporosis Study (CaMos). Osteoporos Int 2000; 11 (08) 680-687
- 12 Ma JB, Wáng YXJ. Chest radiograph prevalence of vertebral deformity among young and middle-aged population of mixed city dwellers and rural residents. J Thorac Dis 2022; 14 (12) 4685-4698
- 13 Wáng YXJ. A summary of our recent evidence-based works on radiographic diagnostics of prevalent osteoporotic vertebral fracture in older men and women. Quant Imaging Med Surg 2023; 13 (03) 1264-1285
- 14 Wáng YXJ, Lu ZH, Leung JCS, Fang ZY, Kwok TCY. Osteoporotic-like vertebral fracture with less than 20% height loss is associated with increased further vertebral fracture risk in older women: the MrOS and MsOS (Hong Kong) year-18 follow-up radiograph results. Quant Imaging Med Surg 2023; 13 (02) 1115-1125
- 15 Nelson DA, Kleerekoper M, Peterson EL. Reversal of vertebral deformities in osteoporosis: measurement error or “rebound”?. J Bone Miner Res 1994; 9 (07) 977-982
- 16 Wáng YXJ. Endplatitis short vertebrae. Quant Imaging Med Surg 2024; 14 (03) 2725-2733
- 17 Wáng YXJ, Diacinti D, Iannacone A. et al. A comparison of radiographic degeneration features of older Chinese women and older Italian Caucasian women with a focus on thoracic spine. Aging Clin Exp Res 2023; 35 (11) 2583-2591
- 18 Mann T, Oviatt SK, Wilson D, Nelson D, Orwoll ES. Vertebral deformity in men. J Bone Miner Res 1992; 7 (11) 1259-1265
- 19 Wáng YXJ, Xiao BH. Estimations of bone mineral density defined osteoporosis prevalence and cutpoint T-score for defining osteoporosis among older Chinese population: a framework based on relative fragility fracture risks. Quant Imaging Med Surg 2022; 12 (09) 4346-4360
- 20 Kanis JA, Johnell O, Oden A. et al. Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int 2000; 11 (08) 669-674
- 21 Ho SC, Bacon WE, Harris T, Looker A, Maggi S. Hip fracture rates in Hong Kong and the United States, 1988 through 1989. Am J Public Health 1993; 83 (05) 694-697
- 22 O'Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ. The prevalence of vertebral deformity in European men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res 1996; 11 (07) 1010-1018
- 23 Pansini F, Bagni B, Bonaccorsi G. et al. Oophorectomy and spine bone density: evidence of a higher rate of bone loss in surgical compared with spontaneous menopause. Menopause 1995; 2: 109-115
- 24 Pongchaiyakul C, Charoensri S, Leerapun T, Wongsiri S, Songpatanasilp T, Taechakraichana N. Prevalence of asymptomatic radiographic vertebral fracture in postmenopausal Thai women. Arch Osteoporos 2020; 15 (01) 78
- 25 Wáng YXJ, Wáng XR, Che-Nordin N, Xu FR, Huang QL. On the possibility of over-diagnosis of osteoporotic vertebral fracture at mid-thoracic level. J Thorac Dis 2019; 11 (12) 5708-5711
- 26 Wáng YXJ. An update of our understanding of radiographic diagnostics for prevalent osteoporotic vertebral fracture in elderly women. Quant Imaging Med Surg 2022; 12 (07) 3495-3514
- 27 Wáng YXJ, Santiago FR, Deng M, Nogueira-Barbosa MH. Identifying osteoporotic vertebral endplate and cortex fractures. Quant Imaging Med Surg 2017; 7 (05) 555-591
- 28 Wáng YXJ, Deng M, He LC, Che-Nordin N, Santiago FR. Osteoporotic vertebral endplate and cortex fractures: a pictorial review. J Orthop Translat 2018; 15: 35-49
- 29 Wáng YXJ, Diacinti D, Yu W. et al. Semi-quantitative grading and extended semi-quantitative grading for osteoporotic vertebral deformity: a radiographic image database for education and calibration. Ann Transl Med 2020; 8 (06) 398
- 30 Du EZ, Wáng YXJ. CT detects more osteoporotic endplate depressions than radiograph: a descriptive comparison of 76 vertebrae. Osteoporos Int 2022; 33 (07) 1569-1577
- 31 Wáng YXJ, Du EZ, Gong J, Cheng X. Interpretation of osteoporotic vertebral deformity on frontal view radiographs of the chest and abdomen: a pictorial review. Quant Imaging Med Surg 2021; 11 (01) 423-442
- 32 Lentle BC, Berger C, Probyn L. et al; CaMos Research Group. Comparative analysis of the radiology of osteoporotic vertebral fractures in women and men: cross-sectional and longitudinal observations from the Canadian Multicentre Osteoporosis Study (CaMos). J Bone Miner Res 2018; 33 (04) 569-579
- 33 Deng M, Kwok TCY, Leung JCS, Leung PC, Wáng YXJ. All osteoporotically deformed vertebrae with >34% height loss have radiographically identifiable endplate/cortex fracture. J Orthop Translat 2018; 14: 63-66
- 34 Antonacci MD, Mody DR, Rutz K, Weilbaecher D, Heggeness MH. A histologic study of fractured human vertebral bodies. J Spinal Disord Tech 2002; 15 (02) 118-126
- 35 Diacinti D, Vitali C, Gussoni G. et al; Research Department of FADOI. Misdiagnosis of vertebral fractures on local radiographic readings of the multicentre POINT (Prevalence of Osteoporosis in INTernal medicine) study. Bone 2017; 101: 230-235
- 36 Wáng YXJ, Diacinti D, Leung JCS. et al. Much lower prevalence and severity of radiographic osteoporotic vertebral fracture in elderly Hong Kong Chinese women than in age-matched Rome Caucasian women: a cross-sectional study. Arch Osteoporos 2021; 16 (01) 174
- 37 Wáng YXJ, Diacinti D, Leung JCS. et al. Further evidence supports a much lower prevalence of radiographic osteoporotic vertebral fracture in Hong Kong Chinese women than in Italian Caucasian women. Arch Osteoporos 2022; 17 (01) 13
- 38 Wáng YXJ. The definition of spine bone mineral density (BMD)-classified osteoporosis and the much inflated prevalence of spine osteoporosis in older Chinese women when using the conventional cutpoint T-score of -2.5. Ann Transl Med 2022; 10 (24) 1421
- 39 Tsai KS. Osteoporotic fracture rate, bone mineral density, and bone metabolism in Taiwan. J Formos Med Assoc 1997; 96 (10) 802-805
- 40 Kung AW. Epidemiology and diagnostic approaches to vertebral fractures in Asia. J Bone Miner Metab 2004; 22 (03) 170-175
- 41 Goodman ZD. Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol 2007; 47 (04) 598-607
- 42 Rosen HN, Vokes TJ, Malabanan AO. et al. The official positions of the International Society for Clinical Densitometry: vertebral fracture assessment. J Clin Densitom 2013; 16 (04) 482-488
- 43 Lentle BC, Prior JC. Osteoporotic vertebral fracture (OVF): diagnosis requires an informed observer. Osteoporos Int 2022; 33 (06) 1409-1410
- 44 Wáng YXJ, Che-Nordin N, Leung JCS, Man Yu BW, Griffith JF, Kwok TCY. Elderly men have much lower vertebral fracture risk than elderly women even at advanced age: the MrOS and MsOS (Hong Kong) year 14 follow-up radiology results. Arch Osteoporos 2020; 15 (01) 176
- 45 Wáng YXJ, Diacinti D, Aparisi Gómez MP. et al. Radiological diagnosis of prevalent osteoporotic vertebral fracture on radiographs: an interim consensus from a group of experts of the ESSR osteoporosis and metabolism subcommittee. . Skeletal Radiol 2024; In press
- 46 Wáng YXJ, Diacinti D, Leung JCS. et al. Conversion of osteoporotic vertebral fracture severity score to osteoporosis T-score equivalent status: a framework and a comparative study of Hong Kong Chinese and Rome Caucasian older women. Arch Osteoporos 2022; 18 (01) 1
- 47 Bergot C, Laval-Jeantet AM, Hutchinson K, Dautraix I, Caulin F, Genant HK. A comparison of spinal quantitative computed tomography with dual energy X-ray absorptiometry in European women with vertebral and nonvertebral fractures. Calcif Tissue Int 2001; 68 (02) 74-82
- 48 Wáng YXJ. For older women, majority of hip fragility fracture and radiological vertebral fragility fracture occur among densitometrically osteoporotic subjects: a literature analysis. Quant Imaging Med Surg 2024; 14 (06) 4202-4214
- 49 Wáng YXJ, Leung JCS, Lam PMS, Kwok TCY. Conversion of osteoporotic-like vertebral fracture severity score to osteoporosis T-score equivalent status: A framework study for older Chinese men. Osteoporos Sarcopenia 2023; 9 (01) 14-21
- 50 Wáng YXJ, Leung JCS, Lam PMS, Kwok TCY. Weak correlation between osteoporotic-like vertebral fracture severity and densitometric T-scores in older Chinese men. Ann Transl Med 2023; 11 (10) 374
- 51 Johnell O, Kanis JA, Oden A. et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res 2005; 20 (07) 1185-1194
- 52 Kherad M, Rosengren BE, Hasserius R. et al. Low clinical relevance of a prevalent vertebral fracture in elderly men—the MrOs Sweden study. Spine J 2015; 15 (02) 281-289
- 53 Waterloo S, Søgaard AJ, Ahmed LA, Damsgård E, Morseth B, Emaus N. Vertebral fractures and self-perceived health in elderly women and men in a population-based cross-sectional study: the Tromsø Study 2007–08. BMC Geriatr 2013; 13: 102
- 54 Wáng YXJ, Liu WH, Diacinti D. et al. Diagnosis and grading of radiographic osteoporotic vertebral deformity by general radiologists after a brief self-learning period. J Thorac Dis 2020; 12 (09) 4702-4710
- 55 Wáng YXJ, Griffith JF, Blake GM. et al. Revision of the 1994 World Health Organization T-score definition of osteoporosis for use in older East Asian women and men to reconcile it with their lifetime risk of fragility fracture. Skeletal Radiol 2024; 53 (04) 609-625