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Am J Perinatol 2025; 42(02): 204-222
DOI: 10.1055/s-0044-1787895
Original Article

Multivariate Analysis of Factors Associated with Feeding Mother's Own Milk at Discharge in Preterm Infants: A Retrospective Cohort Study

Jordan D. Reis
1   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas
2   Department of Pediatrics, Baylor Scott & White Health, Dallas, Texas
,
Mariela Sánchez-Rosado
1   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas
3   Division of Neonatology, Joe DiMaggio Children's Hospital, Hollywood, Florida
,
Daizy Mathai
4   Parkland Hospital and Health System, Dallas, Texas
,
Isabelle Kiefaber
5   Health Systems Research, University of Texas Southwestern Medical Center, Dallas, Texas
,
L Steven Brown
4   Parkland Hospital and Health System, Dallas, Texas
,
Cheryl S. Lair
4   Parkland Hospital and Health System, Dallas, Texas
,
David B. Nelson
6   Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, and Parkland Health, Dallas, Texas
,
Patti Burchfield
1   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas
,
Luc P. Brion 
1   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas
› Author Affiliations Funding None.
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Abstract

Objective This study aimed to develop a predictive model of feeding mother's own milk (MOM) at discharge using social determinants of health (SDOH), maternal and neonatal factors after deliveries at <33 weeks of gestational age (GA), or birth weight <1,500 g.

Study Design Secondary analysis of a retrospective cohort in an inner-city hospital before (Epoch-1, 2018–2019) and after (Epoch-2, 2020–2021) implementing a donor human milk (DHM) program.

Results Among 986 neonates, 495 were born in Epoch-1 (320 Hispanic White, 142 Non-Hispanic Black, and 33 Other) and 491 in Epoch-2 (327, 137, and 27, respectively). Feeding any MOM was less frequent in infants of non-Hispanic Black mothers than in those of Hispanic mothers (p < 0.05) but did not change with epoch (p = 0.46). Among infants who received any MOM, continued feeding MOM to the time of discharge was less frequent in infants of non-Hispanic Black mothers versus those of Hispanic mothers, 94/237 (40%) versus 339/595 (57%; p < 0.05), respectively. In multivariate analysis including SDOH and maternal variables, the odds of feeding MOM at discharge were lower with SDOH including neighborhoods with higher poverty levels, multiparity, substance use disorder, non-Hispanic Black versus Hispanic and young maternal age and increased with GA but did not change after implementing DHM. The predictive model including SDOH, maternal and early neonatal variables had good discrimination (area under the curve 0.85) and calibration and was internally validated. It showed the odds of feeding MOM at discharge were lower in infants of non-Hispanic Black mothers and with feeding DHM, higher need for respiratory support and later initiation of feeding MOM.

Conclusion Feeding MOM at discharge was associated with SDOH, and maternal and neonatal factors but did not change after implementing DHM. Disparity in feeding MOM at discharge was explained by less frequent initiation and shorter duration of feeding MOM but not by later initiation of feeding MOM.

Key Points

  • In this cohort study of preterm infants, factors of feeding MOM at discharge included (1) SDOH; (2) postnatal age at initiation of feeding MOM; and (3) maternal and neonatal factors.

  • Feeding MOM at the time of discharge was less frequent in infants of non-Hispanic Black mothers versus those of Hispanic mothers.

  • Disparity in feeding MOM at discharge was explained by less frequent initiation and shorter duration of MOM feeding but not by later postnatal age at initiation of feeding MOM.

Keywords

social determinants of health - formula - mother's own milk - preterm - donor human milk - neonatal intensive care unit - prognostic model research

Note

Preliminary results were presented as follows: (1) Reis J.D., Sanchez-Rosado M., Kiefaber I., Brion L.P. Time of initiation of pumping versus breastfeeding at discharge of preterm infants. E-poster presentation at the American Academy of Pediatrics National Conference and Exhibition, October 8, 2021. (2) Reis JD, Sánchez-Rosado M, Mathai D, Kiefaber I, Brion LP. Time of Initiation of Pumping vs Breastfeeding at Discharge of Preterm Infants, Poster presentation, Pediatric Academic Societies Meeting, Denver, CO, April 24, 2022.


Authors' Contributions

J.D.R. and M.S-R. conceptualized and designed the study, collected and reviewed data from the medical records, and wrote the first draft of the manuscript. L.P.B. and L.S.B. conducted statistical analyses. P.B., D.M., and I.K. extracted data from the EHR. All authors participated in the interpretation of the data, critically reviewed the revisions, and approved the final manuscript as submitted.


Supplementary Material



Publication History

Received: 31 December 2023

Accepted: 29 May 2024

Article published online:
11 July 2024

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