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Drug Res (Stuttg) 2018; 68(07): 403-409
DOI: 10.1055/s-0044-101752
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial

Yunes Panahi
1   Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
,
Nahid Khalili
2   Department of Endocrinology, Baqiyatallah University of Medical Sciences, Tehran, Iran
,
Ebrahim Sahebi
3   Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box: 1583, Shiraz, Iran
,
Soha Namazi
3   Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box: 1583, Shiraz, Iran
,
Luis E. Simental-Mendía
4   Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
,
Muhammed Majeed
5   Sabinsa Corporation, East Windsor, NJ, United States
,
Amirhossein Sahebkar
6   Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
7   Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
8   School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
› Author Affiliations
Further Information

Publication History

received 15 November 2017

accepted 22 January 2018

Publication Date:
19 February 2018 (online)

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Abstract

Introduction Curcuminoids have been shown to reduce glycemia and related complications in diabetes. In the present study, we evaluated the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients.

Methods T2D patients aged 18–65 years were enrolled in a randomized double-blind placebo-controlled trial and randomly allocated to standard-of-care treatment and dietary advises plus either curcuminoids (daily dose of 500 mg/day co-administered with piperine 5 mg/day) or placebo for a period of 3 months. Glycemic, hepatic and inflammatory parameters were measured at baseline and final conditions.

Results A total of 100 subjects (50 in each group) completed the 3-month period of trial. A significant reduction was found in serum levels of glucose (−9±16 mg/dL vs. −3±11 mg/dL in curcuminoids and placebo groups, respectively; p=0.048), C-peptide (−0.6±0.8 ng/mL vs. 0.02±0.6 ng/mL; p<0.001) and HbA1c (−0.9±1.1% vs. −0.2±0.5%; p<0.001) after curcuminoids supplementation versus placebo group. Additionally, participants in the intervention group showed lower serum alanine aminotransferase (−2±6 vs. −1±5; p=0.032) and aspartate aminotransferase (−3±5 vs. −0.3±4; p=0.002) levels compared with the placebo group. Finally, no significant differences in high-sensitivity C-reactive protein (hs-CRP) concentrations were observed between curcuminoids and placebo groups (p>0.05).

Conclusion The results of the present trial revealed a beneficial effect of curcuminoids plus piperine supplementation on glycemic and hepatic parameters but not on hs-CRP levels in T2D patients.

Key words

Curcuminoids - type 2 diabetes mellitus - homeostatic model assessments - hepatic steatosis index - high-sensitivity C-reactive protein

Institute where the work was conducted: Baqiyatallah Univeristy of Medical Sciences, Tehran, Iran.


 

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