Synthesis 2024; 56(20): 3199-3205
DOI: 10.1055/s-0043-1775386
paper

Regio- and Chemoselective Synthesis of 4,6-Dithia-1,2,9-triazaspiro[4.4]non-2-en-8-ones through an Ultrasound-Promoted One-Pot Sequential Pseudo-Five-Component Reaction

Abdolali Alizadeh
,
Ebrahim Amir Chelebari
,
Reza Rezaiyehraad
We are grateful to the Research Council of Tarbiat Modares University for supporting this work.


Abstract

Spiro-heterocycles have attracted significant interest due to their unique biological properties with fewer side effects compared to traditional drugs. Herein, a novel method is reported for the synthesis of a series of spiro-heterocycles possessing a quinoline motif. The strategy utilizes rhodanine derivatives, hydrazonoyl chlorides, and 2-chloroquinoline-3-carbaldehyde, and proceeds via a one-pot sequential pseudo-five-component reaction. The reactions are found to proceed in a regioselective and chemoselective manner.

Supporting Information



Publication History

Received: 21 January 2024

Accepted after revision: 03 July 2024

Article published online:
22 July 2024

© 2024. Thieme. All rights reserved

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