J Reconstr Microsurg 2024; 40(01): 059-069
DOI: 10.1055/s-0043-1768219
Original Article

Secondary Bony Defects after Soft Tissue Reconstruction in Limb-Threatening Lower Extremity Injuries: Does the Approach to Flap Elevation Matter?

Cynthia E. Burke
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Lily R. Mundy
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Jayesh Gupta
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Alison L. Wong
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Blessing Enobun
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Nathan N. O'Hara
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Abdulai Bangura
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Katherine C. O'Connor
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Julio J. Jauregui
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Nathan F. Miller
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Robert V. O'Toole
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
,
Raymond A. Pensy
1   Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
› Author Affiliations
Funding None.

Abstract

Background Limb-threatening lower extremity injuries often require secondary bone grafting after soft tissue reconstruction. We hypothesized that there would be fewer wound complications when performing secondary bone grafting via a remote surgical approach rather than direct flap elevation.

Methods A retrospective cohort study was performed at a single Level 1 trauma center comparing complications after secondary bone grafting in patients who had undergone previous soft tissue reconstruction after open tibia fractures between 2006 and 2020. Comparing bone grafting via a remote surgical incision versus direct flap elevation, we evaluated wound dehiscence requiring return to the operating room as the primary outcome. Secondary outcomes were deep infection and delayed amputation.

Results We identified 129 patients (mean age: 40 years, 82% male) with 159 secondary bone grafting procedures. Secondary bone grafting was performed via a remote surgical approach in 54% (n = 86) and direct flap elevation in 46% (n = 73) of cases. Wound dehiscence requiring return to the operating room occurred in one patient in the flap elevation group (1%) and none of the patients in the remote surgical approach. The odds of deep wound infection (OR, 1.77; p = 0.31) or amputation (OR, 1.43; p = 0.73) did not significantly differ between surgical approaches. No significant differences were found in complications between the reconstructive surgeon elevating and re-insetting the flap and the orthopaedic trauma surgeon performing the flap elevation and re-inset.

Conclusion Direct flap elevation for secondary bone grafting after soft tissue reconstruction for open tibia fractures did not result in more complications than bone grafting via a remote surgical approach. These findings should reassure surgeons to allow other clinical factors to influence the surgical approach for bone grafting.



Publication History

Received: 21 September 2022

Accepted: 28 February 2023

Article published online:
26 April 2023

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  • References

  • 1 MacKenzie EJ, Bosse MJ, Kellam JF. et al; LEAP Study Group. Factors influencing the decision to amputate or reconstruct after high-energy lower extremity trauma. J Trauma 2002; 52 (04) 641-649
  • 2 MacKenzie EJ, Bosse MJ, Kellam JF. et al. Early predictors of long-term work disability after major limb trauma. J Trauma 2006; 61 (03) 688-694
  • 3 McCarthy ML, MacKenzie EJ, Edwin D, Bosse MJ, Castillo RC, Starr A. LEAP Study Group. Psychological distress associated with severe lower-limb injury. J Bone Joint Surg Am 2003; 85 (09) 1689-1697
  • 4 Edwards CC, Simmons SC, Browner BD, Weigel MC. Severe open tibial fractures. Results treating 202 injuries with external fixation. Clin Orthop Relat Res 1988; (230) 98-115
  • 5 Bosse MJ, MacKenzie EJ, Kellam JF. et al. An analysis of outcomes of reconstruction or amputation after leg-threatening injuries. N Engl J Med 2002; 347 (24) 1924-1931
  • 6 Saddawi-Konefka D, Kim HM, Chung KC. A systematic review of outcomes and complications of reconstruction and amputation for type IIIB and IIIC fractures of the tibia. Plast Reconstr Surg 2008; 122 (06) 1796-1805
  • 7 Bosse MJ, Teague D, Reider L. et al; METRC. METRC. Outcomes after severe distal tibia, ankle, and/or foot trauma: comparison of limb salvage versus transtibial amputation (OUTLET). J Orthop Trauma 2017; 31 (Suppl. 01) S48-S55
  • 8 Fong K, Truong V, Foote CJ. et al. Predictors of nonunion and reoperation in patients with fractures of the tibia: an observational study. BMC Musculoskelet Disord 2013; 14: 103
  • 9 Cho EH, Shammas RL, Carney MJ. et al. Muscle versus fasciocutaneous free flaps in lower extremity traumatic reconstruction: a multicenter outcomes analysis. Plast Reconstr Surg 2018; 141 (01) 191-199
  • 10 Fischer MD, Gustilo RB, Varecka TF. The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. J Bone Joint Surg Am 1991; 73 (09) 1316-1322
  • 11 Paro J, Chiou G, Sen SK. Comparing muscle and fasciocutaneous free flaps in lower extremity reconstruction – Does it matter?. Ann Plast Surg 2016; 76 (Suppl. 03) S213-S215
  • 12 Philandrianos C, Moullot P, Gay AM. et al. Soft tissue coverage in distal lower extremity open fractures: comparison of free anterolateral thigh and free latissimus dorsi flaps. J Reconstr Microsurg 2018; 34 (02) 121-129
  • 13 Dow T, ElAbd R, McGuire C. et al. Outcomes of free muscle flaps versus free fasciocutaneous flaps for lower limb reconstruction following trauma: a systematic review and meta-analysis. J Reconstr Microsurg 2023; 39 (07) 526-539
  • 14 Nelson JA, Fischer JP, Haddock NT. et al. Striving for normalcy after lower extremity reconstruction with free tissue: the role of secondary esthetic refinements. J Reconstr Microsurg 2016; 32 (02) 101-108
  • 15 Azoury SC, Stranix JT, Kovach SJ, Levin LS. Principles of orthoplastic surgery for lower extremity reconstruction: Why is this important?. J Reconstr Microsurg 2021; 37 (01) 42-50
  • 16 Xue EY, Liu FC, Therattil PJ. et al. Abstract: fasciocutaneous free flaps in extremity reconstruction: safety of re-elevation. Plast Reconstr Surg Glob Open 2018; 6 (9, Suppl): 140-140
  • 17 Will RE, Fleming ME, Lafferty PM, Fletcher JW, Cole PA. Low complication rate associated with raising mature flap for tibial nonunion reconstruction. J Trauma 2011; 71 (06) 1709-1714
  • 18 Piwnica-Worms W, Stranix JT, Othman S. et al. Risk factors for lower extremity amputation following attempted free flap limb salvage. J Reconstr Microsurg 2020; 36 (07) 528-533
  • 19 Hoppenfeld S, DeBoer P, Buckley R. Surgical Exposures in Orthopaedics: The Anatomic Approach. Philadelphia: Lippincott Williams & Wilkins; 2012
  • 20 O'Toole RV, Jolissaint J, O'Halloran K. et al. NURD 2.0: Prediction of tibial nonunion after intramedullary nail fixation at any time within 3 months after injury. Injury 2021; 52 (06) 1577-1582
  • 21 Shasti M, Jauregui JJ, Malik A, Slobogean G, Eglseder WA, Pensy RA. Magnitude of soft-tissue defect as a predictor of free flap failures: Does size matter?. J Orthop Trauma 2017; 31 (12) e412-e417
  • 22 Sanati-Mehrizy P, Massenburg BB, Rozehnal JM, Ingargiola MJ, Hernandez Rosa J, Taub PJ. Risk factors leading to free flap failure: analysis from the national surgical quality improvement program database. J Craniofac Surg 2016; 27 (08) 1956-1964
  • 23 Chiou GJ, Chang J. Refinements and secondary surgery after flap reconstruction of the traumatized hand. Hand Clin 2014; 30 (02) 211-223 , vi
  • 24 Yazar S, Lin CH, Lin YT, Ulusal AE, Wei FC. Outcome comparison between free muscle and free fasciocutaneous flaps for reconstruction of distal third and ankle traumatic open tibial fractures. Plast Reconstr Surg 2006; 117 (07) 2468-2475 , discussion 2476–2477
  • 25 Gopal S, Majumder S, Batchelor AG, Knight SL, De Boer P, Smith RM. Fix and flap: the radical orthopaedic and plastic treatment of severe open fractures of the tibia. J Bone Joint Surg Br 2000; 82 (07) 959-966
  • 26 Haykal S, Roy M, Patel A. Meta-analysis of timing for microsurgical free-flap reconstruction for lower limb injury: evaluation of the Godina principles. J Reconstr Microsurg 2018; 34 (04) 277-292
  • 27 Godina M, Arnez ZM, Lister GD. Preferential use of the posterior approach to blood vessels of the lower leg in microvascular surgery. Plast Reconstr Surg 1991; 88 (02) 287-291
  • 28 Natoli RM, Marinos DP, Montalvo RN. et al. Poor agreement between next-generation DNA sequencing and bacterial cultures in orthopaedic trauma procedures. J Bone Joint Surg Am 2022; 104 (06) 497-503
  • 29 Palmer MP, Altman DT, Altman GT. et al. Bacterial identification and visualization of bacterial biofilms adjacent to fracture sites after internal fixation. Genet Test Mol Biomarkers 2022; 26 (02) 70-80
  • 30 Thiele JR, Weiß J, Braig D, Zeller J, Stark GB, Eisenhardt SU. Evaluation of the suprafascial thin ALT flap in foot and ankle reconstruction. J Reconstr Microsurg 2022; 38 (02) 151-159
  • 31 Hernán MA. Causal analyses of existing databases: no power calculations required. J Clin Epidemiol 2022; 144: 203-205