Download PDF
Frauenheilkunde up2date 2017; 11(05): 479-498
DOI: 10.1055/s-0043-123627
Interdisziplinäre Themen
Georg Thieme Verlag KG Stuttgart · New York

Epigenetik: Einfluss auf die fetale Entwicklung

Bettina Brune
,
Thomas Brune
Further Information

Publication History

Publication Date:
08 January 2018 (online)

Also available at
    Permissions and Reprints All articles of this category

„Der Mensch ist mehr als die Summe seiner Gene“. Wurde dieser Satz im Jahr 2002 kurz vor Abschluss des Humanen Genomprojekts (HGP) noch unter ethischen und moralphilosophischen Gesichtspunkten diskutiert, wurde danach schnell klar, dass er auch eine tiefergreifende wissenschaftliche Bedeutung für die gesamte Biologie hat als vorher angenommen.
 

  • Literatur

  • 1 Waddington C. The Epigenotype. Int J of Epidemiol 2012; 41: 10-13
    CrossrefPubMedGoogle Scholar
  • 2 FAO/WHO. Expert Consultation on human vitamin and mineral requirements: Folate and folic acid. Rom: FAO; 2001: 53-62
    Google Scholar
  • 3 Gordon L, Joo J, Powell J. et al. Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Res 2012; 22: 1395-1406
    CrossrefPubMedGoogle Scholar
  • 4 Matsuda M, Yasutomi M. Inhibition of cephalic neural tube closure by 5-azacytidine in neurulating rat embryos in vitro. Anat Embryol 1992; 185: 217-223
    CrossrefPubMedGoogle Scholar
  • 5 Hackett J, Surani M. DNA methylation dynamics during the mammalian life cycle. Philos Trans R Soc Lond B Biol Sci 2013; 368(1609): 20110328
    CrossrefPubMedGoogle Scholar
  • 6 Gicquel C, Gaston V, Mandelbaum J. et al. In-vitro-fertilization may increase the risk of Beckwith-Wiedemann Syndrome related to the abnormal imprinting of the KCNQ10 T gene. Am J Hum Genet 2003; 72: 1338-1341
    CrossrefPubMedGoogle Scholar
  • 7 Zhao J, Goldberg J, Bremner J. et al. Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes 2012; 61: 542-546
    CrossrefPubMedGoogle Scholar
  • 8 Radtke K, Ruf M, Gunter H. et al. Transgenerational impact of intimate partner violence on methylation in the promotor of the glucocorticoid receptor. Transl Psychiatry 2011; 1: e21
    CrossrefPubMedGoogle Scholar
  • 9 Crudo A, Petropoulos S, Moisiadis V. et al. Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects. Endocrinology 2012; 153: 3269-3283
    CrossrefPubMedGoogle Scholar
  • 10 Markunas C, Xu Z, Harlid S. et al. Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. Environ Health Perspect 2014; 122: 1147-1153
    CrossrefPubMedGoogle Scholar
  • 11 Bauer T, Trump S, Ishaque N. et al. Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol Syst Biol 2016; 12: 861
    CrossrefPubMedGoogle Scholar
  • 12 Herberth G, Bauer M, Gasch M. et al. Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers. J Allergy Clin Immunol 2014; 133: 543-550
    CrossrefPubMedGoogle Scholar
  • 13 Yeo M, Berglund K, Hanna M. et al. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promotor. Proc Natl Acad Sci USA 2013; 110: 4315-4320
    CrossrefPubMedGoogle Scholar
  • 14 Hales C, Barker D. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologica 1992; 35: 595-601
    CrossrefPubMedGoogle Scholar
  • 15 Tobi E, Lumey L, Talens R. et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009; 18: 4046-4053
    CrossrefPubMedGoogle Scholar
  • 16 Painter R, Osmond C, Gluckman P. et al. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG 2008; 115: 1243-1249
    CrossrefPubMedGoogle Scholar
  • 17 Plagemann A, Harder T, Brunn M. et al. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol 2009; 587: 4963-4976
    CrossrefPubMedGoogle Scholar
  • 18 Guénard F, Deshaies Y, Cianflone K. et al. Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Proc Natl Acad Sci USA 2013; 110: 11439-11444
    CrossrefPubMedGoogle Scholar
  • 19 Bilbo S, Tsang V. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J 2010; 24: 2104-2115
    CrossrefPubMedGoogle Scholar
  • 20 Stirm L, Salih J, Häring H. et al. Epigenetische Veränderungen im Gestationsdiabetes. Diabetologie und Stoffwechsel 2015; 10: P191
    Article in Thieme ConnectGoogle Scholar
  • 21 Lyko F, Foret S, Kucharski R. et al. The honey bee epigenomes: differential methylation of brain DNA in queens and workers. PLoS Biol 2010; 8: e1000506
    CrossrefPubMedGoogle Scholar
  • 22 Hollingsworth J, Maruoka S, Boon K. et al. In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest 2008; 118: 3462-3469
    PubMedGoogle Scholar
  • 23 Waterland R, Jirtle R. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003; 23: 5293-5300
    CrossrefPubMedGoogle Scholar
  • 24 Dolinoy D. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev 2008; 66: 7-11
    CrossrefPubMedGoogle Scholar
  • 25 Junaid M, Kuizon S, Cardona J. et al. Folic acid supplementation dysregulates gene expression in lymphoblastoid cellsimplications in nutrition. Biochem Biophys Res Commun 2011; 412: 688-692
    CrossrefPubMedGoogle Scholar
  • 26 Cho C, Sánchez-Hernández D, Reza-López S. et al. High folate gestational and post-weaning diets alter hypothalamic feeding pathways by DNA methylation in Wistar rat offspring. Epigenetics 2013; 8: 710-719
    CrossrefPubMedGoogle Scholar
  • 27 Brenseke B, Prater M, Bahamonde J. et al. Current thoughts on maternal nutrition and fetal programming of the metabolic syndrome. J Pregnancy 2013; 368-461
    Google Scholar
  • 28 Richardson S, Daniels C, Gillman M. et al. Society: Donʼt blame the mothers. Nature 2014; 512: 131-132
    CrossrefPubMedGoogle Scholar
  • 29 Lambrot R, Xu C, Saint-Phar S. et al. Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nat Commun 2013; 4: 28-89
    Google Scholar
  • 30 Rodgers A, Morgan C, Bronson S. et al. Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress regulation. J Neurosci 2013; 33: 9003-9012
    CrossrefPubMedGoogle Scholar
  • 31 Mychasiuk R, Harker A, Ilnytskyy S. et al. Paternal stress prior to conception alters DNA methylation and behaviour of developing rat offspring. Neuroscience 2013; 241: 100-105
    CrossrefPubMedGoogle Scholar