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Drug Res (Stuttg) 2018; 68(01): 17-22
DOI: 10.1055/s-0043-116674
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Incorporation of Fluorinated Pyridine in the Side Chain of 4-Aminoquinolines: Synthesis, Characterization and Antibacterial Activity

Reza Ranjbar-Karimi
1   Department of Chemistry, Faculty of Science, Vali-e-Asr University, Rafsanjan, Islamic Republic of Iran
,
Alireza Poorfreidoni
1   Department of Chemistry, Faculty of Science, Vali-e-Asr University, Rafsanjan, Islamic Republic of Iran
› Author Affiliations
Further Information

Publication History

received 13 February 2017

accepted 12 July 2017

Publication Date:
28 August 2017 (online)

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Abstract

A series of hybrid of 4-aminoquinoline and fluorinated pyridine derivatives were synthesized and their chemical structure were confirmed by 19F-NMR, 1H-NMR, 13C-NMR and FT-IR. All compounds were tested against one Gram-positive and one Gram-negative bacteria to assess their in vitro antibacterial activity. Compounds 10a, 10b, 11a and 12b showed moderate antibacterial activity against Gram-positive bacterium, Staphylococcus aureus.

Key words

hydroxy- and amine-functionalized quinoline - pentafluoropyridine - 2,3,5,6-Tetrafluoro-4-phenylsulphonyl pyridine - synthesis - antibacterial activity

Supporting Information

    Supporting Information for this article is available online at http://www.thieme-connect.de/products
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