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DOI: 10.1055/s-0043-105377
Sulfonylharnstoffe – warum immer noch im Einsatz?
Widersprüchliche Datenlage erlaubt keine klare Aussage zur SicherheitPublication History
Publication Date:
24 April 2017 (online)
![](https://www.thieme-connect.de/media/diabetakt/201702/lookinside/thumbnails/58_10-1055-s-0043-105377-1.jpg)
Insgesamt stellt sich die Datenlage rund um die kardiovaskuläre Sicherheit der Therapie mit Sulfonylharnstoffen ausgesprochen widersprüchlich dar. Insbesondere die Diskrepanz zwischen den Daten aus randomisierten klinischen und populationsbasierten Studien machen es derzeit unmöglich, die Sicherheit dieser Therapieoption abschließend zu beurteilen. Die bisher vorliegenden Daten sind erheblichen Limitationen unterworfen und können keine ausreichende Evidenz für die Sicherheit einer Sulfonylharnstofftherapie bieten. Ein klareres Bild wird sich hoffentlich mit den Ergebnissen derzeit laufender, randomisierter klinischer Studien ergeben. Bis diese Daten vorliegen, sollte der Einsatz von Sulfonylharnstoffen jedoch kritisch erfolgen. Mit Blick auf die zwischenzeitlich verfügbaren, kardiovaskulär nachweislich sicheren therapeutischen Alternativen fällt eine medizinische Begründung für den Einsatz von Sulfonylharnstoffen immer schwerer.
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