Planta Med 2022; 88(15): 1491
DOI: 10.1055/s-0042-1759135
Poster Session I

Anticancer Diterpenoids from African Croton Species

M Isyaka∗
1   Natural Products Research Group, Dept. of Chemistry, University of Surrey, UK, Guildford, United Kingdom
2   Pen Resource University, Gombe, Nigeria
3   Department of Chemical Sciences, Federal University of Kashere, Gombe, Nigeria
,
M Langat
1   Natural Products Research Group, Dept. of Chemistry, University of Surrey, UK, Guildford, United Kingdom
4   Royal Botanic Gardens, Kew, Kew, UK
,
E Mas-Claret
1   Natural Products Research Group, Dept. of Chemistry, University of Surrey, UK, Guildford, United Kingdom
4   Royal Botanic Gardens, Kew, Kew, UK
,
T Hodges
1   Natural Products Research Group, Dept. of Chemistry, University of Surrey, UK, Guildford, United Kingdom
,
M Brabner
1   Natural Products Research Group, Dept. of Chemistry, University of Surrey, UK, Guildford, United Kingdom
,
J Munisi
5   Dept of Chem., Univ. of Dar es Salaam, Dar es Salaam, Tanzania
,
B Mbala
6   Dept de Chimie Industry, Univ. de Kinshasa, DR Congo
,
D Mulholland
1   Natural Products Research Group, Dept. of Chemistry, University of Surrey, UK, Guildford, United Kingdom
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We report the chemistry and anticancer activities of three African Croton species, C. mubango Mull. Arg., C. haumanianus J. Leonard and C. dictyophlebodes Radcl. -Sm. Forty-five previously undescribed diterpenoids and thirty known compounds were isolated from these species. NMR, MS, ECD, and DP4+ methods were used to determine the structures. Thirty diterpenoids were submitted to the NCIʼs Development Therapeutics Programme for testing in the NCI 60 anticancer cell line screening programme. Compounds 1 – 5 ([Fig. 1]) exhibited 100% lethality against colon (HCT-116), melanoma (M14), and renal (786 – 0) cancer cell lines whereas compound 6 gave 99%, 89% and 82% cell lethality against melanoma (MALME-3M), renal (UO-31) and ovarian (IGROV1) cancer cell lines respectively at a concentration of 10 – 5 M [1], [2], [3].

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Fig. 1 Anticancer diterpenoids.


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Artikel online veröffentlicht:
12. Dezember 2022

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  • References

  • 1 Isyaka MS, Langat MK, Mas-Claret E. et al. Ent-abietane and ent-pimarane diterpenoids from Croton mubango (Euphorbiaceae). Phytochemistry 2020; 170: 112217
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  • 2 Isyaka MS, Mas-Claret E, Langat MK. et al. Cytotoxic diterpenoids from the leaves and stem bark of Croton haumanianus (Euphorbiaceae). Phytochemistry 2020; 178: 112455
    CrossrefPubMedSuche in Google Scholar
  • 3 Musisi JJE, Isyaka MS, Mas-Claret E. et al. Ent-clerodane and ent-trachylobane diterpenoids from the stem bark and root of Croton dictyophlebodes. Phytochemistry 2020; 179: 112487
    CrossrefPubMedSuche in Google Scholar