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Semin Thromb Hemost 2023; 49(04): 402-408
DOI: 10.1055/s-0042-1757900
Review Article

New Horizons in Fetal and Neonatal Alloimmune Thrombocytopenia

Assaf Barg
1   National Hemophilia Center, Sheba Medical Center, Amalia Biron Research Institute of Thrombosis and Hemostasis, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
,
Lilach Bonstein
2   Blood Bank and Platelet Immunology Laboratories, Rambam Health Care Campus, Haifa, Israel
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Abstract

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a common cause of severe thrombocytopenia in newborns. Intracranial bleeding may lead to severe neurological sequelae and mortality. Current management of pregnancies at risk is suboptimal. Prenatal FNAIT diagnosis commonly requires invasive procedures and therapy is associated with a high treatment burden. The present review explores advances in the field and their potential contribution to modification of the diagnostic and therapeutic landscape. Topics addressed include the role of noninvasive prenatal testing using fetal cell free DNA, insights into novel and prospective therapeutic options achieved through the development of murine models of FNAIT as well as the forecast for the progress in pregnancy risk stratification through advancement in the investigation of biological characteristics of alloantibodies and their association with the risk of fetal bleeding.

Keywords

bleeding - neonatal - pregnancy - thrombocytopenia - alloimmune - diagnosis


Publication History

Article published online:
11 November 2022

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