Arylation and Alkyne Insertion to C-Acylimines: Rapid Access to 2-Trifluoromethylated and Other Fully Substituted Pyrroles in One Pot

Abstract

A one-pot, four-component strategy for the synthesis of trifluoromethylated, and other fully-substituted pyrroles is reported using minimum loading of calcium catalyst at room temperature. A variety of arenes, α-keto aldehydes, amines, and activated alkynes took part in the reaction to produce high-yielding products. Friedel–Crafts arylation and aza-Michael addition are the key reactions in this approach.

Key words

C-acylimines - trifluoromethyl pyrroles - multicomponent reaction - green chemistry - Friedel–Crafts arylation - calcium catalyst

Publication History

Received: 21 November 2022

Accepted after revision: 19 December 2022

Article published online:
11 January 2023

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