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Klin Monbl Augenheilkd 2017; 234(07): 868-873
DOI: 10.1055/s-0042-124513
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Potenziale und Limitationen der Detektion von zirkulierenden Melanomzellen

Potentials and Limitations of the Detection of Circulating Melanoma Cells
J. Lüke
Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck
,
S. Grisanti
Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck
,
A. Tura
Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck
› Institutsangaben
Weitere Informationen

Publikationsverlauf

eingereicht 21. Oktober 2016

akzeptiert 09. Dezember 2016

Publikationsdatum:
13. Februar 2017 (online)

Auch verfügbar auf
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Zusammenfassung

Die Bestimmung und Charakterisierung zirkulierender Melanomzellen ist ein nicht invasives und komplikationsarmes Verfahren mit dem Potenzial, einen choroidalen Nävus von einem choroidalen Melanom abzugrenzen und frühzeitig einer Therapie zuführen zu können. Zukünftig bietet es die Chance, das therapeutische Ansprechen zu überwachen und bei der Therapieauswahl zu helfen. Es besteht die Hoffnung, weitere Erkenntnisse hinsichtlich des Metastasierungsprozesses zu gewinnen und damit Ansatzpunkte für die Entwicklung zielgerichteter Therapien. In diesem Artikel werden die verschiedenen Techniken der Bestimmung zirkulierender Tumorzellen vorgestellt und ihr Potenzial bzw. Limitationen diskutiert.

Abstract

The detection and characterisation of circulating melanoma cells (CMC) is a non-invasive procedure with a low complication rate and can potentially distinguish choroidal nevi from uveal melanomas and help to initiate early adequate therapy. It has the perspective to select and monitor treatment. This technique may lead to new insights into the metastasis process itself and help to detect specific targets for future therapies. This article introduces the different techniques for CMC detection; their potentials and limitations are discussed.

Schlüsselwörter

Aderhautnävi - uveales Melanom - zirkulierende Melanomzellen - Metastasen

Key words

choroidal nevi - uveal melanoma - circulating melanoma cells - metastasis
 

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