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Horm Metab Res 2017; 49(03): 164-173
DOI: 10.1055/s-0042-121605
Review
© Georg Thieme Verlag KG Stuttgart · New York

Systematic Review and Meta-Analysis of Randomized, Controlled Trials on the Effect of Exercise on Serum Leptin and Adiponectin in Overweight and Obese Individuals

Na Yu   *
1   The Second Clinical College of Southern Medical University, Guangzhou, China
,
Yuting Ruan   *
2   Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
,
Xiaoyan Gao
1   The Second Clinical College of Southern Medical University, Guangzhou, China
,
Jia Sun
2   Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
3   Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
› Author Affiliations
Further Information

Publication History

received 14 May 2016

accepted 09 November 2016

Publication Date:
01 March 2017 (online)

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Abstract

Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals; however, results to date are controversial. Here we performed a systematic review and meta-analysis of the available randomized controlled trials (RCTs) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals. We searched PubMed, EMbase, The Cochrane Library, and the Clinicaltrial.gov databases for relevant studies published between January 1980 and September 2015. Two independent reviewers extracted relevant data and assessed study quality and risk of bias. Data were pooled using a random-effects model for leptin and a fixed-effects model for adiponectin. Effect of size was expressed as mean difference (MD) with 95% confidence interval (CI). Heterogeneity was assessed (Cochran Q-statistic) and quantified (I 2 ). Twenty-eight RCTs (40 studies) were identified, of which 24 were on the effects of exercise on leptin (n=1 358) and 31 referred to changes in adiponectin (n=1 774). Our analysis revealed that exercise significantly reduced serum leptin (MD=−2.24 ng/ml; 95% CI, −3.26, −1.23; p<0.001) and increased adiponectin (MD=0.44 μg/ml; 95% CI, 0.13, 0.75; p=0.005) levels compared to no exercise as well as control (who were also overweight or obese). Exercise, particularly aerobic exercise, had a significant effect on serum leptin and a possible influence on adiponectin levels, suggesting its therapeutic implications.

Key words

obesity - overweight - exercise - leptin - adiponectin

* These authors contributed equally to this work


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  • References

  • 1 Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf) 2006; 64: 355-365
    PubMedGoogle Scholar
  • 2 Tabak AG, Brunner EJ, Miller MA, Karanam S, McTernan PG, Cappuccio FP, Witte DR. Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation: Whitehall II study. Horm Metab Res 2009; 41: 626-629
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Mattu HS, Randeva HS. Role of adipokines in cardiovascular disease. J Endocrinol 2013; 216: T17-T36
    CrossrefPubMedGoogle Scholar
  • 4 Liao LM, Schwartz K, Pollak M, Graubard BI, Li Z, Ruterbusch J, Rothman N, Davis F, Wacholder S, Colt J, Chow WH, Purdue MP. Serum Leptin and Adiponectin Levels and Risk of Renal Cell Carcinoma. Obesity 2013; 21: 1478-1485
    CrossrefPubMedGoogle Scholar
  • 5 Arditi JD, Venihaki M, Karalis KP, Chrousos GP. Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer. Horm Metab Res 2007; 39: 9-13
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Hart CN, Carskadon MA, Considine RV, Fava JL, Lawton J, Raynor HA, Jelalian E, Owens J, Wing R. Changes in children’s sleep duration on food intake, weight, and leptin. Pediatrics 2013; 132: e1473-e1480
    CrossrefPubMedGoogle Scholar
  • 7 Takefuji S, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Matsushita K, Sugiura K, Hotta Y, Mitsuhashi H, Oiso Y, Toyoshima H. Smoking status and adiponectin in healthy Japanese men and women. Prev Med 2007; 45: 471-475
    CrossrefPubMedGoogle Scholar
  • 8 Salehi-Abargouei A, Izadi V, Azadbakht L. The effect of low calorie diet on adiponectin concentration: a systematic review and meta-analysis. Horm Metab Res 2015; 47: 549-555
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 1985; 100: 126-131
    PubMedGoogle Scholar
  • 10 Gondim OS, de Camargo VT, Gutierrez FA, Martins PF, Passos ME, Momesso CM, Santos VC, Gorjao R, Pithon-Curi TC, Cury-Boaventura MF. Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults. PloS One 2015; 10: e0140596
    CrossrefPubMedGoogle Scholar
  • 11 Halaas JL, Friedman JM. Leptin and its receptor. J Endocrinol 1997; 155: 215-216
    CrossrefPubMedGoogle Scholar
  • 12 Owecki M, Nikisch E, Miczke A, Pupek-Musialik D, Sowinski J. Leptin soluble leptin receptors, free leptin index, and their relationship with insulin resistance and BMI: high normal BMI is the threshold for serum leptin increase in humans. Horm Metab Res 2010; 42: 585-589
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Stefan N, Stumvoll M. Adiponectin – its role in metabolism and beyond. Horm Metab Res 2002; 34: 469-474
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Nielsen S, Lihn AS, Taaa OS, Mogensen CE, Schmitz O. Increased plasma adiponectin in losartan-treated type 1 diabetic patients. a mediator of improved insulin sensitivity?. Horm Metab Res 2004; 36: 194-196
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Passos MC, Goncalves MC. Regulation of insulin sensitivity by adiponectin and its receptors in response to physical exercise. Horm Metab Res 2014; 46: 603-608
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Madsen EL, Rissanen A, Bruun JM, Skogstrand K, Tonstad S, Hougaard DM, Richelsen B. Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study. Eur J Endocrinol 2008; 158: 179-187
    CrossrefPubMedGoogle Scholar
  • 17 Zeng Q, Isobe K, Fu L, Ohkoshi N, Ohmori H, Takekoshi K, Kawakami Y. Effects of exercise on adiponectin and adiponectin receptor levels in rats. Life Sci 2007; 80: 454-459
    CrossrefPubMedGoogle Scholar
  • 18 Auerbach P, Nordby P, Bendtsen LQ, Mehlsen JL, Basnet SK, Vestergaard H, Ploug T, Stallknecht B. Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. Am J Physiol Regul Integr Comp Physiol 2013; 305: R490-R498
    CrossrefPubMedGoogle Scholar
  • 19 Karacabey K. The effect of exercise on leptin, insulin, cortisol and lipid profiles in obese children. J Int Med Res 2009; 37: 1472-1478
    CrossrefPubMedGoogle Scholar
  • 20 Kim YS, Nam JS, Yeo DW, Kim KR, Suh SH, Ahn CW. The effects of aerobic exercise training on serum osteocalcin, adipocytokines and insulin resistance on obese young males. Clin Endocrinol (Oxf) 2015; 82: 686-694
    CrossrefPubMedGoogle Scholar
  • 21 Kim YS, Nam JS, Yeo DW, Kim KR, Suh SH, Ahn CW. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Med Sci Sports Exerc 2012; 44: 2099-2110
    CrossrefPubMedGoogle Scholar
  • 22 Lee JA, Kim JW, Kim DY. Effects of yoga exercise on serum adiponectin and metabolic syndrome factors in obese postmenopausal women. Menopause 2012; 19: 296-301
    CrossrefPubMedGoogle Scholar
  • 23 Salvadori A, Fanari P, Brunani A, Marzullo P, Codecasa F, Tovaglieri I, Cornacchia M, Palmulli P, Longhini E. Leptin level lowers in proportion to the amount of aerobic work after four weeks of training in obesity. Horm Metab Res 2015; 47: 225-231
    Article in Thieme ConnectPubMedGoogle Scholar
  • 24 Bhutani S, Klempel MC, Kroeger CM, Trepanowski JF, Phillips SA, Norkeviciute E, Varady KA. Alternate day fasting with or without exercise: Effects on endothelial function and adipokines in obese humans. e-SPEN J 2013; 8: e205-e209
    PubMedGoogle Scholar
  • 25 Abbenhardt C, McTiernan A, Alfano CM, Wener MH, Campbell KL, Duggan C, Foster-Schubert KE, Kong A, Toriola AT, Potter JD, Mason C, Xiao L, Blackburn GL, Bain C, Ulrich CM. Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels. J Intern Med 2013; 274: 163-175
    CrossrefPubMedGoogle Scholar
  • 26 Ligibel JA, Giobbie-Hurder A, Olenczuk D, Campbell N, Salinardi T, Winer EP, Mantzoros CS. Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors. Cancer Causes Control 2009; 20: 1523-1528
    CrossrefPubMedGoogle Scholar
  • 27 Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 2007; 56: 1005-1009
    CrossrefPubMedGoogle Scholar
  • 28 Winzer BM, Paratz JD, Whitehead JP, Whiteman DC, Reeves MM. The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. PloS One 2015; 10: e0117922
    CrossrefPubMedGoogle Scholar
  • 29 Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ. Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults. J Am Geriatr Soc 2013; 61: 1089-1094
    CrossrefPubMedGoogle Scholar
  • 30 Higgins JPT.GS. http://handbook.cochrane.org 2011
    PubMed
  • 31 Venojarvi M, Wasenius N, Manderoos S, Heinonen OJ, Hernelahti M, Lindholm H, Surakka J, Lindstrom J, Aunola S, Atalay M, Eriksson JG. Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation. Ann Med 2013; 45: 162-170
    CrossrefPubMedGoogle Scholar
  • 32 Ackel-D’Elia C, Carnier J, Bueno Jr. CR, Campos RM, Sanches PL, Clemente AP, Tufik S, de Mello MT, Damaso AR. Effects of different physical exercises on leptin concentration in obese adolescents. Int J Sports Med 2014; 35: 164-171
    Article in Thieme ConnectPubMedGoogle Scholar
  • 33 Asad M, Ravasi AA, Faramarzi M, Pournemati P. The effects of three training methods endurance, resistance and concurrent on adiponectin resting levels in overweighed untrained men. Bratisl Lek Listy 2012; 113: 664-668
    PubMedGoogle Scholar
  • 34 Barbeau P, Gutin B, Litaker MS, Ramsey LT, Cannady WE, Allison J, Lemmon CR, Owens S. Influence of physical training on plasma leptin in obese youths. Can J Appl Physiol 2003; 28: 382-396
    CrossrefPubMedGoogle Scholar
  • 35 Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, Manousaki M, Douroudos I, Taxildaris K, Mitrakou A. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 2005; 90: 5970-5977
    CrossrefPubMedGoogle Scholar
  • 36 Racil G, Ben Ounis O, Hammouda O, Kallel A, Zouhal H, Chamari K, Amri M. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. Eur J Appl Physiol 2013; 113: 2531-2540
    CrossrefPubMedGoogle Scholar
  • 37 Hara T, Fujiwara H, Nakao H, Mimura T, Yoshikawa T, Fujimoto S. Body composition is related to increase in plasma adiponectin levels rather than training in young obese men. Eur J Appl Physiol 2005; 94: 520-526
    CrossrefPubMedGoogle Scholar
  • 38 Johannsen NM, Swift DL, Johnson WD, Dixit VD, Earnest CP, Blair SN, Church TS. Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW. PloS One 2012; 7: e31319
    CrossrefPubMedGoogle Scholar
  • 39 Marcell TJ, McAuley KA, Traustadottir T, Reaven PD. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 2005; 54: 533-541
    CrossrefPubMedGoogle Scholar
  • 40 Murphy EC, Carson L, Neal W, Baylis C, Donley D, Yeater R. Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children. Int J Pediatr Obes 2009; 4: 205-214
    CrossrefPubMedGoogle Scholar
  • 41 Miller GD, Nicklas BJ, Davis CC, Ambrosius WT, Loeser RF, Messier SP. Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?. Int J Obes Relat Metab Disord 2004; 28: 1383-1390
    CrossrefPubMedGoogle Scholar
  • 42 Norton K, Norton L, Sadgrove D. Position statement on physical activity and exercise intensity terminology. J Sci Med Sport 2010; 13: 496-502
    CrossrefPubMedGoogle Scholar
  • 43 Moghadasi M, Mohebbi H, Rahmani-Nia F, Hassan-Nia S, Noroozi H. Effects of short-term lifestyle activity modification on adiponectin mRNA expression and plasma concentrations. Eur J Sport Sci 2013; 13: 378-385
    CrossrefPubMedGoogle Scholar
  • 44 Kraemer RR, Kraemer GR, Acevedo EO, Hebert EP, Temple E, Bates M, Etie A, Haltom R, Quinn S, Castracane VD. Effects of aerobic exercise on serum leptin levels in obese women. Eur J Appl Physiol Occup Physiol 1999; 80: 154-158
    CrossrefPubMedGoogle Scholar
  • 45 Kim ES, Im JA, Kim KC, Park JH, Suh SH, Kang ES, Kim SH, Jekal Y, Lee CW, Yoon YJ, Lee HC, Jeon JY. Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth. Obesity 2007; 15: 3023-3030
    CrossrefPubMedGoogle Scholar
  • 46 Brochu-Gaudreau K, Rehfeldt C, Blouin R, Bordignon V, Murphy BD, Palin MF. Adiponectin action from head to toe. Endocrine 2010; 37: 11-32
    CrossrefPubMedGoogle Scholar
  • 47 Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Molecular and Cellular Endocrinology 2010; 316: 129-139
    CrossrefPubMedGoogle Scholar
  • 48 Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J Sports Med 2010; 44: 620-630
    CrossrefPubMedGoogle Scholar
  • 49 Brandt C, Jakobsen AH, Adser H, Olesen J, Iversen N, Kristensen JM, Hojman P, Wojtaszewski JF, Hidalgo J, Pilegaard H. IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice. Acta Physiol (Oxf) 2012; 205: 224-235
    CrossrefPubMedGoogle Scholar
  • 50 Straub RH, Tanko LB, Christiansen C, Larsen PJ, Jessop DS. Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women. J Endocrinol 2008; 199: 61-68
    CrossrefPubMedGoogle Scholar
  • 51 Schwingshackl L, Dias S, Strasser B, Hoffmann G. Impact of different training modalities on anthropometric and metabolic characteristics in overweight/obese subjects: a systematic review and network meta-analysis. PloS One 2013; 8: e82853
    CrossrefPubMedGoogle Scholar
  • 52 Metcalf BS, Jeffery AN, Hosking J, Voss LD, Sattar N, Wilkin TJ. Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (EarlyBird 38). Diabetes care 2009; 32: 468-473
    CrossrefPubMedGoogle Scholar
  • 53 Simpson KA, Singh MA. Effects of exercise on adiponectin: a systematic review. Obesity 2008; 16: 241-256
    CrossrefPubMedGoogle Scholar
  • 54 Klimcakova E, Kovacikova M, Stich V, Langin D. Adipokines and dietary interventions in human obesity. Obes Rev 2010; 11: 446-456
    CrossrefPubMedGoogle Scholar
  • 55 Golbidi S, Laher I. Exercise induced adipokine changes and the metabolic syndrome. J Diabetes Res 2014 2014: 726861
    PubMed
  • 56 Hayashino Y, Jackson JL, Hirata T, Fukumori N, Nakamura F, Fukuhara S, Tsujii S, Ishii H. Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: a meta-analysis of randomized controlled trials. Metabolism 2014; 63: 431-440
    CrossrefPubMedGoogle Scholar