Clin Colon Rectal Surg 2022; 35(02): 113-121
DOI: 10.1055/s-0041-1742111
Review Article

The Role of Transanal Endoscopic Surgery for Early Rectal Cancer

Natalie F. Berger
1   Icahn School of Medicine at Mount Sinai, New York, New York
,
Patricia Sylla
1   Icahn School of Medicine at Mount Sinai, New York, New York
2   Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai Hospital, New York, New York
› Author Affiliations
Funding None.

Abstract

Transanal endoscopic surgery (TES), which is performed through a variety of transanal endoluminal multitasking surgical platforms, was developed to facilitate endoscopic en bloc excision of rectal lesions as a minimally invasive alternative to radical proctectomy. Although the oncologic safety of TES in the treatment of malignant rectal tumors has been an area of vigorous controversy over the past two decades, TES is currently accepted as an oncologically safe approach for the treatment of carefully selected early and superficial rectal cancers. TES can also serve as both a diagnostic and potentially curative treatment of partially resected unsuspected malignant polyps. In this article, indications and contraindications for transanal endoscopic excision of early rectal cancer lesions are reviewed, as well as selection criteria for the most appropriate transanal excisional approach. Preoperative preparation and surgical technique for complications of TES will be reviewed, as well as recommended surveillance and management of upstaged tumors.



Publication History

Article published online:
28 February 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Read B, Sylla P. Aggressive colorectal cancer in the young. Clin Colon Rectal Surg 2020; 33 (05) 298-304
  • 2 Maurer CA, Renzulli P, Kull C. et al. The impact of the introduction of total mesorectal excision on local recurrence rate and survival in rectal cancer: long-term results. Ann Surg Oncol 2011; 18 (07) 1899-1906
  • 3 Snijders HS, Wouters MW, van Leersum NJ. et al. Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. Eur J Surg Oncol 2012; 38 (11) 1013-1019
  • 4 Marijnen CA, Kapiteijn E, van de Velde CJ. et al; Cooperative Investigators of the Dutch Colorectal Cancer Group. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 2002; 20 (03) 817-825
  • 5 Guillou PJ, Quirke P, Thorpe H. et al; MRC CLASICC trial group. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 2005; 365 (9472): 1718-1726
  • 6 Hompes R, Rauh SM, Ris F, Tuynman JB, Mortensen NJ. Robotic transanal minimally invasive surgery for local excision of rectal neoplasms. Br J Surg 2014; 101 (05) 578-581
  • 7 de Graaf EJ, Burger JW, van Ijsseldijk AL, Tetteroo GW, Dawson I, Hop WC. Transanal endoscopic microsurgery is superior to transanal excision of rectal adenomas. Colorectal Dis 2011; 13 (07) 762-767
  • 8 Christoforidis D, Cho HM, Dixon MR, Mellgren AF, Madoff RD, Finne CO. Transanal endoscopic microsurgery versus conventional transanal excision for patients with early rectal cancer. Ann Surg 2009; 249 (05) 776-782
  • 9 Lee TG, Lee SJ. Transanal single-port microsurgery for rectal tumors: minimal invasive surgery under spinal anesthesia. Surg Endosc 2014; 28 (01) 271-280
  • 10 Hahnloser D, Cantero R, Salgado G, Dindo D, Rega D, Delrio P. Transanal minimal invasive surgery for rectal lesions: should the defect be closed?. Colorectal Dis 2015; 17 (05) 397-402
  • 11 Albert MR, Atallah SB, deBeche-Adams TC, Izfar S, Larach SW. Transanal minimally invasive surgery (TAMIS) for local excision of benign neoplasms and early-stage rectal cancer: efficacy and outcomes in the first 50 patients. Dis Colon Rectum 2013; 56 (03) 301-307
  • 12 Lee L, Burke JP, deBeche-Adams T. et al. Transanal minimally invasive surgery for local excision of benign and malignant rectal neoplasia: outcomes from 200 consecutive cases with midterm follow up. Ann Surg 2018; 267 (05) 910-916
  • 13 Bridoux V, Schwarz L, Suaud L, Dazza M, Michot F, Tuech JJ. Transanal minimal invasive surgery with the Endorec(TM) trocar: a low cost but effective technique. Int J Colorectal Dis 2014; 29 (02) 177-181
  • 14 Blumberg D, Paty PB, Guillem JG. et al. All patients with small intramural rectal cancers are at risk for lymph node metastasis. Dis Colon Rectum 1999; 42 (07) 881-885
  • 15 Kaltenbach T, Anderson JC, Burke CA. et al. Endoscopic removal of colorectal lesions-recommendations by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology 2020; 158 (04) 1095-1129
  • 16 Moss A, Bourke MJ, Williams SJ. et al. Endoscopic mucosal resection outcomes and prediction of submucosal cancer from advanced colonic mucosal neoplasia. Gastroenterology 2011; 140 (07) 1909-1918
  • 17 Hayashi N, Tanaka S, Hewett DG. et al. Endoscopic prediction of deep submucosal invasive carcinoma: validation of the Narrow-Band Imaging International Colorectal Endoscopic (NICE) classification. Gastrointest Endosc 2013; 78 (04) 625-632
  • 18 Matsuda T, Parra-Blanco A, Saito Y, Sakamoto T, Nakajima T. Assessment of likelihood of submucosal invasion in non-polypoid colorectal neoplasms. Gastrointest Endosc Clin N Am 2010; 20 (03) 487-496
  • 19 Kobayashi N, Saito Y, Sano Y. et al. Determining the treatment strategy for colorectal neoplastic lesions: endoscopic assessment or the non-lifting sign for diagnosing invasion depth?. Endoscopy 2007; 39 (08) 701-705
  • 20 Quaresima S, Balla A, D'Ambrosio G. et al. Endoluminal loco-regional resection by TEM after R1 endoscopic removal or recurrence of rectal tumors. Minim Invasive Ther Allied Technol 2016; 25 (03) 134-140
  • 21 Serra-Aracil X, Pallisera-Lloveras A, Mora-Lopez L. et al. Transanal endoscopic surgery is effective and safe after endoscopic polypectomy of potentially malignant rectal polyps with questionable margins. Colorectal Dis 2018; 20 (09) 789-796
  • 22 Schäfer HH, Vivaldi C, Hölscher AH. Local excision with transanal endoscopic microsurgery (TEM) after endoscopic R1/R2-polypectomy of pT1 “low-risk” carcinomas of the rectum. Z Gastroenterol 2006; 44 (08) 647-650
  • 23 Melis M, Gruel R, Darwin P, Drachenberg C, Shibata D. Full thickness transanal re-excision following endoscopic removal of malignant rectal polyps. Int J Colorectal Dis 2009; 24 (05) 531-536
  • 24 Kawaguti FS, Nahas CS, Marques CF. et al. Endoscopic submucosal dissection versus transanal endoscopic microsurgery for the treatment of early rectal cancer. Surg Endosc 2014; 28 (04) 1173-1179
  • 25 Park SU, Min YW, Shin JU. et al. Endoscopic submucosal dissection or transanal endoscopic microsurgery for nonpolypoid rectal high grade dysplasia and submucosa-invading rectal cancer. Endoscopy 2012; 44 (11) 1031-1036
  • 26 Jung Y, Lee J, Cho JY. et al. Comparison of efficacy and safety between endoscopic submucosal dissection and transanal endoscopic microsurgery for the treatment of rectal tumor. Saudi J Gastroenterol 2018; 24 (02) 115-121
  • 27 Salinas HM, Dursun A, Klos CL. et al. Determining the need for radical surgery in patients with T1 rectal cancer. Arch Surg 2011; 146 (05) 540-543
  • 28 Yamamoto S, Watanabe M, Hasegawa H. et al. The risk of lymph node metastasis in T1 colorectal carcinoma. Hepatogastroenterology 2004; 51 (58) 998-1000
  • 29 Glasgow SC, Bleier JI, Burgart LJ, Finne CO, Lowry AC. Meta-analysis of histopathological features of primary colorectal cancers that predict lymph node metastases. J Gastrointest Surg 2012; 16 (05) 1019-1028
  • 30 Ha RK, Han KS, Sohn DK. et al. Histopathologic risk factors for lymph node metastasis in patients with T1 colorectal cancer. Ann Surg Treat Res 2017; 93 (05) 266-271
  • 31 Doornebosch PG, Zeestraten E, de Graaf EJ. et al. Transanal endoscopic microsurgery for T1 rectal cancer: size matters!. Surg Endosc 2012; 26 (02) 551-557
  • 32 Bach SP, Hill J, Monson JR. et al; Association of Coloproctology of Great Britain and Ireland Transanal Endoscopic Microsurgery (TEM) Collaboration. A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Br J Surg 2009; 96 (03) 280-290
  • 33 Bosch SL, Teerenstra S, de Wilt JH, Cunningham C, Nagtegaal ID. Predicting lymph node metastasis in pT1 colorectal cancer: a systematic review of risk factors providing rationale for therapy decisions. Endoscopy 2013; 45 (10) 827-834
  • 34 Ueno H, Hase K, Hashiguchi Y. et al. Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review. J Gastroenterol 2014; 49 (09) 1314-1323
  • 35 Kikuchi R, Takano M, Takagi K. et al. Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines. Dis Colon Rectum 1995; 38 (12) 1286-1295
  • 36 Stojkovic Lalosevic M, Milovanovic T, Micev M. et al. Perineural invasion as a prognostic factor in patients with stage I-III rectal cancer - 5-year follow up. World J Gastrointest Oncol 2020; 12 (05) 592-600
  • 37 Liebig C, Ayala G, Wilks J. et al. Perineural invasion is an independent predictor of outcome in colorectal cancer. J Clin Oncol 2009; 27 (31) 5131-5137
  • 38 Zhang G, Cai YZ, Xu GH. Diagnostic accuracy of MRI for assessment of T category and circumferential resection margin involvement in patients with rectal cancer: a meta-analysis. Dis Colon Rectum 2016; 59 (08) 789-799
  • 39 Oien K, Forsmo HM, Rösler C, Nylund K, Waage JE, Pfeffer F. Endorectal ultrasound and magnetic resonance imaging for staging of early rectal cancers: how well does it work in practice?. Acta Oncol 2019; 58 (sup1): S49-S54
  • 40 Wan LJ, Liu Y, Peng WJ. et al. Submucosal enhancing stripe as a contrast material-enhanced MRI-based imaging feature for the differentiation of stage T0-T1 from early T2 rectal cancers. Radiology 2021; 298 (01) 93-101
  • 41 Arezzo A, Passera R, Marchese N, Galloro G, Manta R, Cirocchi R. Systematic review and meta-analysis of endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal lesions. United European Gastroenterol J 2016; 4 (01) 18-29
  • 42 Barendse RM, Musters GD, de Graaf EJR. et al; TREND Study group. Randomised controlled trial of transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND Study). Gut 2018; 67 (05) 837-846
  • 43 Mao W, Liao X, Shao S, Wu W, Yu Y, Yang G. Comparative evaluation of colonoscopy-assisted transanal minimally invasive surgery via glove port and endoscopic submucosal dissection for early rectal tumor. Int J Surg 2017; 42: 197-202
  • 44 Dekkers N, Boonstra JJ, Moons LMG. et al. Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial. BMC Gastroenterol 2020; 20 (01) 225
  • 45 Junginger T, Goenner U, Hitzler M. et al. Long-term results of transanal endoscopic microsurgery after endoscopic polypectomy of malignant rectal adenoma. Tech Coloproctol 2017; 21 (03) 225-232
  • 46 Antonelli G, Vanella G, Orlando D, Angeletti S, Di Giulio E. Recurrence and cancer-specific mortality after endoscopic resection of low- and high-risk pT1 colorectal cancers: a meta-analysis. Gastrointest Endosc 2019; 90 (04) 559-569.e3
  • 47 Jones HJS, Al-Najami I, Baatrup G, Cunningham C. Local excision after polypectomy for rectal polyp cancer: when is it worthwhile?. Colorectal Dis 2021; 23 (04) 868-874
  • 48 Floyd ND, Saclarides TJ. Transanal endoscopic microsurgical resection of pT1 rectal tumors. Dis Colon Rectum 2006; 49 (02) 164-168
  • 49 Palma P, Horisberger K, Joos A, Rothenhoefer S, Willeke F, Post S. Local excision of early rectal cancer: is transanal endoscopic microsurgery an alternative to radical surgery?. Rev Esp Enferm Dig 2009; 101 (03) 172-178
  • 50 Tsai BM, Finne CO, Nordenstam JF, Christoforidis D, Madoff RD, Mellgren A. Transanal endoscopic microsurgery resection of rectal tumors: outcomes and recommendations. Dis Colon Rectum 2010; 53 (01) 16-23
  • 51 Guerrieri M, Gesuita R, Ghiselli R, Lezoche G, Budassi A, Baldarelli M. Treatment of rectal cancer by transanal endoscopic microsurgery: experience with 425 patients. World J Gastroenterol 2014; 20 (28) 9556-9563
  • 52 Junginger T, Goenner U, Hitzler M. et al. Long-term oncologic outcome after transanal endoscopic microsurgery for rectal carcinoma. Dis Colon Rectum 2016; 59 (01) 8-15
  • 53 O'Neill CH, Platz J, Moore JS, Callas PW, Cataldo PA. Transanal endoscopic microsurgery for early rectal cancer: a ingle-center experience. Dis Colon Rectum 2017; 60 (02) 152-160
  • 54 Jones HJS, Hompes R, Mortensen N, Cunningham C. Modern management of T1 rectal cancer by transanal endoscopic microsurgery: a 10-year single-centre experience. Colorectal Dis 2018; 20 (07) 586-592
  • 55 Lee W, Lee D, Choi S, Chun H. Transanal endoscopic microsurgery and radical surgery for T1 and T2 rectal cancer. Surg Endosc 2003; 17 (08) 1283-1287
  • 56 De Graaf EJ, Doornebosch PG, Tollenaar RA. et al. Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intention. Eur J Surg Oncol 2009; 35 (12) 1280-1285
  • 57 You YN, Baxter NN, Stewart A, Nelson H. Is the increasing rate of local excision for stage I rectal cancer in the United States justified? A nationwide cohort study from the National Cancer Database. Ann Surg 2007; 245 (05) 726-733
  • 58 Kulu Y, Müller-Stich BP, Bruckner T. et al. Radical surgery with total mesorectal excision in patients with T1 rectal cancer. Ann Surg Oncol 2015; 22 (06) 2051-2058
  • 59 Hwang Y, Yoon YS, Bong JW. et al. Long-term transanal excision outcomes in patients with T1 rectal cancer: comparative analysis of radical resection. Ann Coloproctol 2019; 35 (04) 194-201
  • 60 Nastro P, Beral D, Hartley J, Monson JR. Local excision of rectal cancer: review of literature. Dig Surg 2005; 22 (1-2): 6-15
  • 61 National Comprehensive Cancer Network (NCCN) Guidelines in Oncology. Rectal Cancer. NCCN; . Published 2020. Updated December 22, 2020. Accessed December 31, 2020 at: https://www.nccn.org/professionals/physician_gls/pdf/rectal.pdf
  • 62 Borschitz T, Heintz A, Junginger T. The influence of histopathologic criteria on the long-term prognosis of locally excised pT1 rectal carcinomas: results of local excision (transanal endoscopic microsurgery) and immediate reoperation. Dis Colon Rectum 2006; 49 (10) 1492-1506 , discussion 1500–1505
  • 63 Levic K, Bulut O, Hesselfeldt P, Bülow S. The outcome of rectal cancer after early salvage TME following TEM compared with primary TME: a case-matched study. Tech Coloproctol 2013; 17 (04) 397-403
  • 64 Borstlap WA, Coeymans TJ, Tanis PJ. et al. Meta-analysis of oncological outcomes after local excision of pT1-2 rectal cancer requiring adjuvant (chemo)radiotherapy or completion surgery. Br J Surg 2016; 103 (09) 1105-1116
  • 65 Dulskas A, Atkociunas A, Kilius A, Petrulis K, Samalavicius NE. Is previous transanal endoscopic microsurgery for early rectal cancer a risk factor of worse outcome following salvage surgery a case-matched analysis. Visc Med 2019; 35 (03) 151-155
  • 66 Kahi CJ, Boland CR, Dominitz JA. et al; United States Multi-Society Task Force on Colorectal Cancer. Colonoscopy surveillance after colorectal cancer resection: recommendations of the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology 2016; 150 (03) 758-768.e11
  • 67 Madbouly KM, Remzi FH, Erkek BA. et al. Recurrence after transanal excision of T1 rectal cancer: should we be concerned?. Dis Colon Rectum 2005; 48 (04) 711-719 , discussion 719–721
  • 68 Paty PB, Nash GM, Baron P. et al. Long-term results of local excision for rectal cancer. Ann Surg 2002; 236 (04) 522-529 , discussion 529–530
  • 69 Weiser MR, Landmann RG, Wong WD. et al. Surgical salvage of recurrent rectal cancer after transanal excision. Dis Colon Rectum 2005; 48 (06) 1169-1175