Niv Score Is A Reliable Index For Evaluating Small Bowel Involvement In Pediatric Crohn’S Disease Patients

Aims Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract, predominantly involving the small intestine and colon. Up to 66 % of patients with Crohn’s disease have small-bowel involvement at diagnosis. Ileocolonoscopy is the gold standard in the diagnosis of ileocolonic disease but skip lesions and proximal involvement can be evaluated only by the meaning of capsule endoscopy (VCE) and or MR enterography (MRE). The aim of the study was to correlate findings obtained from MRE and VCE with Paediatric Crohn’s disease Activity Index (PDCAI) at the time of disease presentation.

Methods At a single-center, tertiary care hospital center we included 52 subjects, 35 boys and 17 girls with a mean age of 14.0 years. After the upper and lower endoscopy was performed, we assessed PCDAI and all patients with suspected small bowel involvement underwent both MRE (1.5 T MRI system, evaluated by Crohn disease MRI index – CDMI) and VCE (SB 3, evaluated by the Capsule Endoscopy Crohn’s Disease Activity Index - CECDAI or Niv).

Results Mean PCDAI value was 21.3, comparable by sex of the participants but correlating positively and significantly with age (r=0.393; p = 0.004). All CECDAI parameters (proximal, distal, summary) as well as CDMI correlated statistically significantly (p < 0.01) and positively (r > 0.5) with PCDAI. Two regression models were evaluated. In the first stepwise model, summary CECDAI was left as the only independent predictor, (R² = 0.337). In a similar model, but with CDMI as a predictor, R² was only marginally lower with a value of 0.332, with other independent variables (age, gender…) excluded from the model as well. Both models were statistically significant at p < 0.001.

Conclusions Both summary CECDAI and CDMI were remarkably similar as predictors of the PDCAI as the objective parameter of the disease.

Citation Hauser G, Palcevski G, Candrlic B et al. eP461 NIV SCORE IS A RELIABLE INDEX FOR EVALUATING SMALL BOWEL INVOLVEMENT IN PEDIATRIC CROHN’S DISEASE PATIENTS. Endoscopy 2021; 53: S248.

Publication History

Article published online:
19 March 2021