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Am J Perinatol 2022; 39(10): 1112-1116
DOI: 10.1055/s-0040-1721690
Original Article

Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Tamer A. Abdel-Hamid
1   Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt
,
Dalia AbdelLatif
1   Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt
,
Eman Ahmed
2   Pediatrics Department, Alhayat Hospital, Alhayat, Egypt
,
Mazen Abdel-Rasheed 
3   Reproductive Health Research Department, National Research Centre, Egypt
,
Ahmed A-Mageed
4   Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
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Abstract

Objective Maternal malnutrition with disturbed lipid metabolism during pregnancy may affect the fetal lipid profile. We aimed to detect the relation between maternal and neonatal serum lipid profile, as well as to detect the serum lipid profile difference between small for gestational age (SGA) infants and appropriate for gestational age (AGA) infants to disclose the impact of maternal malnutrition on birth weight.

Study Design A cross-sectional study was conducted on 150 pregnant women coming to the labor room. Before delivery, maternal serum levels of high-density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides (TGs), and total cholesterol were assessed, then after delivery, cord blood samples were taken for assessment of the neonatal lipid profile. Birth weights were measured, then the neonates were divided into SGA and AGA groups.

Results Serum levels of LDL, TGs, and total cholesterol in the SGA infants were lower than that in the AGA infants. A positive correlation between maternal and neonatal serum TGs levels was found. Besides, there was a positive correlation between birth weight and maternal serum levels of LDL, TGs, and total cholesterol.

Conclusion Maternal serum lipid profile could be an indicator of the neonatal serum lipid profile and birth weight.

Key Points

  • SGA neonates have lower levels of serum lipids compared to AGA neonates.

  • There is a positive correlation between maternal and neonatal triglycerides.

  • There is a positive correlation between birth weight and maternal serum lipids.

Keywords

total cholesterol - triglycerides - LDL - HDL - small for gestational age - birth weight

Note

This study was approved by the medical ethical committee of the Faculty of Medicine, Cairo University. All mothers participated voluntarily; privacy and confidentiality of data were assured all through the research work. Informed consent was taken from them.


Authors' Contribution

Each author participated actively in conducting analyses, drafting sections of the manuscript, editing, and approving the final, submitted version. The manuscript has not been previously published or submitted to another journal for publication. All authors have seen and approved the manuscript being submitted.




Publication History

Received: 03 August 2020

Accepted: 02 November 2020

Article published online:
15 December 2020

© 2020. Thieme. All rights reserved.

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