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DOI: 10.1055/s-0040-1721055
The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons
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Abstract
Introduction Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.
Materials and Methods All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.
Results A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09–1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant (p = 0.677 and p = 0.206, respectively).
Conclusion We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.
Keywords
hypertrophic pyloric stenosis - infantile hypertrophic pyloric stenosis - incidence - seasonal variation - epidemiologyPublication History
Received: 18 June 2020
Accepted: 09 October 2020
Article published online:
10 November 2020
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
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References
- 1 Aspelund G, Langer JC. Current management of hypertrophic pyloric stenosis. Semin Pediatr Surg 2007; 16 (01) 27-33
- 2 Jobson M, Hall NJ. Contemporary management of pyloric stenosis. Semin Pediatr Surg 2016; 25 (04) 219-224
- 3 Peters B, Oomen MW, Bakx R, Benninga MA. Advances in infantile hypertrophic pyloric stenosis. Expert Rev Gastroenterol Hepatol 2014; 8 (05) 533-541
- 4 Panteli C. New insights into the pathogenesis of infantile pyloric stenosis. Pediatr Surg Int 2009; 25 (12) 1043-1052
- 5 Zhu J, Zhu T, Lin Z, Qu Y, Mu D. Perinatal risk factors for infantile hypertrophic pyloric stenosis: A meta-analysis. J Pediatr Surg 2017; 52 (09) 1389-1397
- 6 Dodge JA. Infantile hypertrophic pyloric stenosis in Belfast, 1957-1969. Arch Dis Child 1975; 50 (03) 171-178
- 7 Carneiro PM. Infantile hypertrophic pyloric stenosis in Dar Es Salaam. Cent Afr J Med 1991; 37 (03) 93-96
- 8 Kerr AM. Unprecedented rise in incidence of infantile hypertrophic pyloric stenosis. BMJ 1980; 281 (6242): 714-715
- 9 MacMahon B. The continuing enigma of pyloric stenosis of infancy: a review. Epidemiology 2006; 17 (02) 195-201
- 10 Kapoor R, Kancherla V, Cao Y. et al. Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: a multistate, population-based retrospective study, 1999-2010. Birth Defects Res 2019; 111 (03) 159-169
- 11 Safford SD, Pietrobon R, Safford KM, Martins H, Skinner MA, Rice HE. A study of 11,003 patients with hypertrophic pyloric stenosis and the association between surgeon and hospital volume and outcomes. J Pediatr Surg 2005; 40 (06) 967-972
- 12 de Laffolie J, Turial S, Heckmann M, Zimmer KP, Schier F. Decline in infantile hypertrophic pyloric stenosis in Germany in 2000-2008. Pediatrics 2012; 129 (04) e901-e906
- 13 Yau A, Cha R, Jayaratnam S. et al. Declining incidence of pyloric stenosis in New Zealand. ANZ J Surg 2019; 89 (10) 1242-1245
- 14 Svenningsson A, Svensson T, Akre O, Nordenskjöld A. Maternal and pregnancy characteristics and risk of infantile hypertrophic pyloric stenosis. J Pediatr Surg 2014; 49 (08) 1226-1231
- 15 Zamakhshary MF, Dutta S, To T, Stephens D, Langer JC, Wales PW. Seasonal variation of hypertrophic pyloric stenosis: a population-based study. Pediatr Surg Int 2011; 27 (07) 689-693
- 16 Adelstein P, Fedrick J. Pyloric stenosis in the Oxford Record Linkage Study area. J Med Genet 1976; 13 (06) 439-448
- 17 Webb AR, Lari J, Dodge JA. Infantile hypertrophic pyloric stenosis in South Glamorgan 1970-9. Effects of changes in feeding practice. Arch Dis Child 1983; 58 (08) 586-590
- 18 Walsworth-Bell JP. Infantile hypertrophic pyloric stenosis in Greater Manchester. J Epidemiol Community Health 1983; 37 (02) 149-152
- 19 Pedersen RN, Garne E, Loane M, Korsholm L, Husby S. EUROCAT Working Group. Infantile hypertrophic pyloric stenosis: a comparative study of incidence and other epidemiological characteristics in seven European regions. J Matern Fetal Neonatal Med 2008; 21 (09) 599-604
- 20 Kwok RH, Avery G. Seasonal variation of congenital hypertrophic pyloric stenosis. J Pediatr 1967; 70 (06) 963-965
- 21 Campbell MA. The question of seasonal variation of pyloric stenosis. J Pediatr 1969; 74 (06) 1006-1007
- 22 Tiao MM, Tsai SS, Kuo HW, Yang CY. Epidemiological features of infantile hypertrophic pyloric stenosis in Taiwan: a national study 1996-2004. J Gastroenterol Hepatol 2011; 26 (01) 78-81
- 23 Leong MM, Chen SC, Hsieh CS. et al. Epidemiological features of infantile hypertrophic pyloric stenosis in Taiwanese children: a nation-wide analysis of cases during 1997-2007. PLoS One 2011; 6 (05) e19404
- 24 Habbick BF, To T. Incidence of infantile hypertrophic pyloric stenosis in Saskatchewan, 1970-85. CMAJ 1989; 140 (04) 395-398
- 25 Centraal Bureau voor de Statistiek. CBS Statline (database), Statistics Netherlands. Accessed November 2018 at: http://statline.cbs.nl
- 26 Sommerfield T, Chalmers J, Youngson G, Heeley C, Fleming M, Thomson G. The changing epidemiology of infantile hypertrophic pyloric stenosis in Scotland. Arch Dis Child 2008; 93 (12) 1007-1011
- 27 Lisonkova S, Joseph KS. Similarities and differences in the epidemiology of pyloric stenosis and SIDS. Matern Child Health J 2014; 18 (07) 1721-1727
- 28 Hedbäck G, Abrahamsson K, Husberg B, Granholm T, Odén A. The epidemiology of infantile hypertrophic pyloric stenosis in Sweden 1987-96. Arch Dis Child 2001; 85 (05) 379-381
- 29 Applegate MS, Druschel CM. The epidemiology of infantile hypertrophic pyloric stenosis in New York State, 1983 to 1990. Arch Pediatr Adolesc Med 1995; 149 (10) 1123-1129
- 30 Rosenthal YS, Chodick G, Grossman Z, Shalev V, Koren G. The incidence of infantile hypertrophic pyloric stenosis and its association with folic acid supplementation during pregnancy: a nested case-control study. J Pediatr Surg 2019; 54 (04) 701-706
- 31 Stark CM, Rogers PL, Eberly MD, Nylund CM. Association of prematurity with the development of infantile hypertrophic pyloric stenosis. Pediatr Res 2015; 78 (02) 218-222
- 32 Abdellatif M, Ghozy S, Kamel MG. et al. Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. Eur J Pediatr 2019; 178 (03) 301-314
- 33 McAteer JP, Ledbetter DJ, Goldin AB. Role of bottle feeding in the etiology of hypertrophic pyloric stenosis. JAMA Pediatr 2013; 167 (12) 1143-1149
- 34 Peeters D, Lanting CI, Van Wouwe JP. 2015 Peiling Melkvoeding Van Zuigelingen. TNO, Leiden 2015