Synlett 2021; 32(17): 1711-1713
DOI: 10.1055/s-0040-1720385
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A Simple, Readily Accessible, and Effective Apparatus for the ­Photoisomerization of cis-Cyclooctenes to trans-Cyclooctenes

a   Department of Medicinal Chemistry, Biotherapeutic and Medicinal Sciences, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, USA
b   Antisense Oligonucleotide Development and Manufacturing; Analytical Development, Biogen, 115 Broadway, Cambridge, Massachusetts 02142, USA
,
a   Department of Medicinal Chemistry, Biotherapeutic and Medicinal Sciences, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, USA
,
Kevin M. Guckian
a   Department of Medicinal Chemistry, Biotherapeutic and Medicinal Sciences, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, USA
,
Xianglin Shi
b   Antisense Oligonucleotide Development and Manufacturing; Analytical Development, Biogen, 115 Broadway, Cambridge, Massachusetts 02142, USA
› Author Affiliations


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Abstract

A simple, cost effective, and readily accessible apparatus for the photoisomerization of cis-cyclooctenes to trans-cyclooctenes is described. Utilizing only FEP tubing, aluminum vent pipe, a household germicidal lamp, and a flash chromatography system, trans-cyclooctenes can be prepared in good yield.

Supporting Information



Publication History

Received: 25 May 2021

Accepted after revision: 07 July 2021

Article published online:
30 July 2021

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