Synthesis of a Maleimide-Diaminoterephthalate Fluorescence Dye as a ‘Turn-On’ Probe for the Detection of Thiols

Abstract

A fluorescence ‘turn-on’ probe for the detection of thiols was prepared in three steps. A diaminoterephthalate chromophore (λ_abs = 472 nm) was equipped with a maleimide moiety as reactive group. Upon conjugate addition of the thiol, the fluorescence intensity is increased by a factor of about twenty (λ_em = 567 nm, quantum yield Φ = 1% → 14%). The probe is used to establish a quantitative assay for glutathione.

Key words

diaminoterephthalate - dye - fluorescence - glutathione - maleimide - thiol - turn-on probe

Publikationsverlauf

Eingereicht: 13. Oktober 2021

Angenommen nach Revision: 17. Dezember 2021

Artikel online veröffentlicht:
09. Februar 2022

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